Carboranyl thymidine analogues for neutron capture therapy.
Carboranyl thymidine analogues for neutron capture therapy.
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用于中子捕获治疗的碳硼烷基胸苷类似物。
DOI：
10.1039/b707257k
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Barth,RolfF
中科院分区：
文献类型：
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作者：
Tjarks,Werner;Tiwari,Rohit;Byun,Youngjoo;Narayanasamy,Sureshbabu;Barth,RolfF
中子俘获治疗（NCT）是一种治疗癌症的二元放化疗方式。NCT相关研究的一个主要焦点是开发作为NCT化学成分的新型肿瘤选择性药物。胸腺嘧啶类似物在N3位置被含硼碳硼烷簇取代，称为3cta（3-碳硼基胸腺嘧啶类似物），构成了一类新的改进的NCT剂。本文讨论了它们的化学、结构和生物学特性。
Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.