Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
复制标题
全身施用血清素激动剂对大鼠面部运动神经元影响的细胞内研究。
DOI：
10.1016/0014-2999(82)90242-4
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发表时间：
1982
影响因子：
5
通讯作者：
Aghajanian,GK
中科院分区：
文献类型：
--
作者：
Vandermaelen,CP;Aghajanian,GK
对引起行为性血清素综合征的5-甲氧基- n， n -二甲基色胺n -二甲基色胺（5-MeODMT）和对氯安非他明（PCA）麻醉大鼠的面部运动神经元进行细胞内记录。这两种药物引起缓慢的去极化，增加输入阻力，增加面部运动神经元的兴奋性。这些变化与5 -羟色胺直接应用于这些神经元引起的变化相同，并且可能是行为5 -羟色胺综合征的一些组成部分的基础。
Intracellular recordings were made from facial motoneurons of anesthetized rats during systemitic administration of 5-methoxy-N,N-dimethyltryptamine N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to those caused by direct microiontophoretic application of serotonin to these neurons, and probably underlie some of the components of the behavioral serotonin syndrome.