FISH OIL DECREASES NATURAL-RESISTANCE OF MICE TO INFECTION WITH SALMONELLA-TYPHIMURIUM
FISH OIL DECREASES NATURAL-RESISTANCE OF MICE TO INFECTION WITH SALMONELLA-TYPHIMURIUM
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DOI：
10.1016/0026-0495(92)90181-9
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发表时间：
1992-01-01
影响因子：
9.8
通讯作者：
PECHERE, JC
中科院分区：
文献类型：
--
作者：
CHANG, HR;DULLOO, AG;PECHERE, JC
与那些喂食富含玉米油或氢化椰子油的食物或低脂食物的小鼠相比，喂食鱼油4周的小鼠在用鼠伤寒沙门氏菌进行非常低的经口（PO）攻击后的死亡率显著较高。喂食鱼油饮食的存活小鼠中没有一只在脾脏中显示出细菌计数，而喂食高脂肪或低脂肪饮食的存活小鼠中有45.4%至66.6%。喂食鱼油的小鼠的脾脏在腹腔内感染相同的细菌菌株后7天呈现出最高的细菌数量。因此，目前的研究表明，富含鱼油的饮食会降低宿主对感染的抵抗力。
Mortality rate in mice fed fish oil for 4 weeks was remarkably higher after a very low peroral (PO) challenge withSalmonella typhimurium, as compared with those fed diets rich in either corn oil or hydrogenated coconut oil, or a low fat (chow) diet. None of the surviving mice fed the fish oil diet showed bacterial counts in their spleens, unlike 45.4% to 66.6% of surviving mice fed high fat or low fat diets. The spleens of mice fed fish oil presented the highest number of bacteria 7 days after intraperitoneal infection with the same bacterial strain. Thus, the current studies demonstrate that a diet rich in fish oil decreases host resistance to infection.