A functional interaction between the mesolimbic dopamine system and vasopressin release in the regulation of blood pressure in conscious rats
A functional interaction between the mesolimbic dopamine system and vasopressin release in the regulation of blood pressure in conscious rats
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DOI：
10.1016/s0306-4522(97)00157-7
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发表时间：
1997-11-01
期刊：
影响因子：
3.3
通讯作者：
VandenBuuse, M
中科院分区：
文献类型：
--
作者：
Cornish, JL;Wilks, DP;VandenBuuse, M
本研究的目的是进一步表征中边缘多巴胺系统在中枢血压调节中的参与，特别强调该系统与循环加压素作用的相互作用。在清醒的大鼠中，我们通过将 P 物质类似物 DiMe-C7（[pGlu(5)、MePhe(8)、Sar(9)]-物质 P5-11；10 nmol）注射到腹侧被盖区，刺激中脑边缘/中皮质末梢释放内源性多巴胺。腹侧被盖区的化学刺激导致血压和心率显着增加。这些效应可以通过下丘脑视上核的双侧电解损伤或通过多巴胺 D-2 受体拮抗剂雷氯必利 (0.5 mg/kg) 的全身预处理来预防。腹侧被盖区的刺激还导致视上核中原癌基因c-fos的表达显着增加，并且血浆加压素水平显着增加，表明该核中的加压素能神经元被激活。然而，雷氯必利预处理并没有显着抑制腹侧被盖区的这种刺激作用。我们认为微量注射DiMe-C7刺激腹侧中脑对血压和心率的影响是该区域多巴胺能和非多巴胺能细胞体联合激活的结果。刺激腹侧中脑中的非多巴胺能细胞可能通过激活视上核而诱导血浆加压素水平适度增加。对腹侧中脑多巴胺能细胞的额外刺激使得循环加压素水平的增加表现为加压反应，这可能是通过抑制加压素诱导的压力反射反应的促进来实现的。 (C) 1997 国际广播组织。由爱思唯尔科学有限公司出版
The aim of the present study was to further characterize the involvement of the mesolimbic dopamine system in central blood pressure regulation, with particular emphasis on the interaction of this system with the effects of circulating vasopressin. In conscious rats we stimulated the release of endogenous dopamine from mesolimbic/mesocortical terminals by administration of the substance P analogue DiMe-C7 ([pGlu(5), MePhe(8), Sar(9)]-Substance P5-11; 10 nmol) into the ventral tegmental area. Chemical stimulation of the ventral tegmental area resulted in a significant increase in blood pressure and heart rate. These effects were prevented by either bilateral electrolytic lesions of the hypothalamic supraoptic nucleus or by systemic pretreatment with the dopamine D-2 receptor antagonist raclopride (0.5 mg/kg). Stimulation of the ventral tegmental area also produced a marked increase in the expression of the proto-oncogene c-fos in the supraoptic nucleus and a significant Increase in plasma vasopressin levels, suggesting activation of vasopressinergic neurons in this nucleus. However, this effect of stimulation of the ventral tegmental area was not significantly inhibited by pretreatment with raclopride.We suggest that the effects on blood pressure and heart rate of stimulation of the ventral midbrain by micro-injection of DiMe-C7 are the result of combined activation of both dopaminergic and non-dopaminergic cell bodies in this region. Stimulation of non-dopaminergic cells in the ventral midbrain may induce a moderate increase in plasma vasopressin levels by activation of the supraoptic nucleus. An additional stimulation of dopaminergic cells in the ventral midbrain allows the increase in circulating vasopressin levels to become manifest as a presser response, possibly by inhibition of vasopressin-induced facilitation of baroreflex responses. (C) 1997 IBRO. Published by Elsevier Science Ltd.