T cell memory and protective immunity by vaccination: is more better?
T cell memory and protective immunity by vaccination: is more better?
复制标题
疫苗接种带来的 T 细胞记忆和保护性免疫力：越多越好吗？
DOI：
10.1016/j.it.2006.09.004
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发表时间：
2006
影响因子：
16.8
通讯作者：
Franchini,Genoveffa
中科院分区：
文献类型：
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作者：
Zanetti,Maurizio;Franchini,Genoveffa
对细胞内病原体或肿瘤抗原的保护需要T细胞介导的反应。最近，对疾病的保护在许多情况下与中央记忆类型的T细胞相关，这一点已经变得明显。在这里，我们分析当前的数据，以提炼出一套诱导和维持中央记忆T细胞反应的规则。最近的研究表明，T细胞的帮助和启动时没有明显的炎症反应是记忆T细胞诱导、维持和扩增的先决条件。我们的假设的核心是，除了这些因素外，在免疫经验不足的人中成功接种疫苗应该基于较低的抗原剂量，以减缓反应细胞的复制衰老，并有利于中央记忆T细胞的谱系分化。对于有免疫经验的人，在接种疫苗之前，还需要减少血浆中的抗原负荷。这些指导原则可能有助于通过接种疫苗提高人类保护性T细胞反应。
Protection against intracellular pathogens or tumor antigens requires T-cell mediated responses. Recently, it has become apparent that protection against disease correlates with T cells of the central memory type in many instances. Here, we analyze current data to distill a set of rules for the induction and maintenance of central memory T-cell responses. Recent studies show that T-cell help and the lack of overt inflammation at the time of priming are prerequisite for the induction, maintenance and expansion of memory T cells. Central to our hypothesis is that, in addition to these factors, successful vaccination in the immunologically inexperienced individual should be based on low antigen dose, to decelerate replicative senescence in responding cells and favor lineage differentiation of central memory T cells. In the immunologically experienced individual, it will be necessary, in addition, to abate the antigen load in plasma before vaccination. These guiding principles might help to raise improved protective T-cell responses by vaccination in humans.