OPHTHALMOLOGIC CHANGES RELATED TO RADIATION EXPOSURE AND AGE IN ADULT HEALTH STUDY SAMPLE, HIROSHIMA AND NAGASAKI
OPHTHALMOLOGIC CHANGES RELATED TO RADIATION EXPOSURE AND AGE IN ADULT HEALTH STUDY SAMPLE, HIROSHIMA AND NAGASAKI
复制标题
DOI：
10.2307/3576122
复制
发表时间：
1983-01-01
影响因子：
3.4
通讯作者：
OTAKE, M
中科院分区：
文献类型：
--
作者：
CHOSHI, K;TAKAKU, I;OTAKE, M
1978年至1980年，对广岛和长崎原子弹爆炸幸存者的年龄和与辐射相关的眼科损害进行了为期两年的眼科研究。这两个城市的研究样本由所有暴露在100+rad以上的人、他们的对照组和所有其他有轴向混浊或后囊下改变记录的人组成。大多数损失是由于拒绝参加或在定期体检时无法安排眼科检查的人造成的。对照组和100+rad组的人员损失不随城市年龄的增长而有系统的变化。作为正常老化过程的表现，暴露组和对照组随着年龄的增长，晶状体混浊增加、其他晶状体改变以及视力和调节能力的丧失也会发生。在广岛，与对照组相比，300+rad组所有年龄段的眼轴浑浊和后囊下改变都有非常显著的额外风险，但在长崎没有观察到。在广岛，对于轰炸时15岁的人(ATB)，观察到更强的放射敏感性老化效应，表现为轴向混浊和后囊下改变。
A 2-yr ophthalmologic study of age and radiation-related ophthalmologic lesions among the atomic bomb survivors in Hiroshima and Nagasaki was conducted in 1978-1980. The study sample in both cities was composed of all persons exposed to 100+ rad, their controls and all other persons with a previous record of axial opacities or posterior subcapsular changes. Most losses were due to persons who refused to participate or for whom it was not possible to arrange for an ophthalmologic examination at the time of the regularly scheduled medical examination. The loss of persons in the control and the 100+ rad groups did not change systematically with increasing age by city. Increased lenticular opacities, other lens changes and loss of visual acuity and accommodation occurred with increasing age in exposed and control subjects as manifestations of the normal aging process. A highly significant excess risk for all age categories in the 300+ rad group in comparison to those in the control group was observed for axial opacities and posterior subcapsular changes in Hiroshima, but not in Nagasaki. A stronger radiosensitive aging effect for persons who were 15 yr old at the time of the bombing (ATB) was observed for axial opacities and posterior subcapsular changes in Hiroshima.