Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway
Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway
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DOI：
10.1016/j.ejphar.2010.10.057
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发表时间：
2011-01-15
影响因子：
5
通讯作者：
Wang, Hui
中科院分区：
文献类型：
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作者：
Ping, Jie;Li, Jing-ting;Wang, Hui
在肝纤维化过程中，肝星状细胞（HSC）的增殖以及随后过量的细胞外基质成分的合成是已知的中心事件。因此，可能限制HSC增殖的因素是潜在的抗纤维化药物。本研究旨在探讨从芸苔科蔬菜中提取的营养成分吲哚-3-甲醇（I3C）对体外培养HSC增殖的影响，并阐明其潜在的分子机制。用I3C（50、100和200 μ M）处理活化的大鼠HSC- t6 24 h，结果表明I3C在有或没有血小板衍生生长因子- bb （PDGF-BB）刺激的情况下均能以浓度依赖的方式显著抑制HSC增殖(P
During the course of liver fibrogenesis, hepatic stellate cell (HSC) proliferation as well as subsequent synthesis of excessive extracellular matrix components is known to be the central events. Thus, factors that could limit HSC proliferation are potential anti-fibrotic agents. The aim of this study was to investigate the effects of indole-3-carbinol (I3C), a nutritional component derived from Brassica family vegetables, on the proliferation of cultured HSC and to clarify the underline molecular mechanism. HSC-T6, an activated rat HSC line, was treated with I3C (50, 100 and 200 mu M) for 24 h. The results indicated that I3C can significantly inhibit HSC proliferation in a concentration-dependent manner with or without platelet-derived growth factor-BB (PDGF-BB) stimulation (P