Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type 1 diabetic children
Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type 1 diabetic children
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DOI：
10.1006/jaut.1996.0096
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发表时间：
1996-12-01
影响因子：
12.8
通讯作者：
Bougneres, PF
中科院分区：
文献类型：
--
作者：
Carel, JC;Boitard, C;Bougneres, PF
我们在具有临床前糖尿病的免疫学和代谢标准的糖尿病患者的一级亲属中进行了低剂量环孢素的免疫抑制的初步研究：胰岛细胞抗体（伊卡）大于或等于20青少年糖尿病基金会（JDF）单位，第一时相胰岛素反应< 10（th）百分位数和葡萄糖耐量受损。环孢素的初始剂量为7.5 mg/kg*d，第一年结束后逐渐减少。6个环孢素治疗的亲属进行了比较，9个历史对照，随后在同一或不同的中心。所有未经治疗的患者在12个月内（5.9 +/- 1.1个月）发生糖尿病。四名环孢菌素治疗的受试者在进入试验后的5、24、24和47个月时发展为糖尿病，而另外两名在进入试验后的47和57个月时是非糖尿病的（至糖尿病的时间> 34 +/-8个月，P < 0.001 vs对照组; Mann-Whitney检验）。2例患者第一时相胰岛素反应增加至正常值。这些结果表明，可逆的功能障碍，与β细胞破坏，有助于临床前1型糖尿病胰岛素分泌的失败。(C)1996年学术出版社
We conducted a pilot study of immunosuppression with low dose cyclosporine in first degree relatives of diabetic patients with immunologic and metabolic criteria for preclinical diabetes: islet cell antibodies (ICA) greater than or equal to 20 Juvenile Diabetes Foundation (JDF) units, first phase insulin response < 10(th) percentile and impaired glucose tolerance. Cyclosporine was given at an initial dose of 7.5 mg/kg*d and tapered after the end of the first year. Six cyclosporine-treated relatives were compared to nine historical controls followed at the same or at different centres. All untreated patients developed diabetes within 12 months (5.9 +/- 1.1 months). Four of the cyclosporine-treated subjects developed diabetes at 5, 24, 24 and 47 months while the other two are non diabetic 47 and 57 months after entry into the trial (time to diabetes > 34 +/- 8 months, P < 0.001 vs the control group; Mann-Whitney test). First phase insulin response increased to normal values in two patients. These results suggest that reversible functional impairment, in association with beta-cell destruction, contributes to the failure of insulin secretion in preclinical type 1 diabetes. (C) 1996 Academic Press Limited