Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
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DOI：
10.1038/ni1009
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发表时间：
2003-12-01
影响因子：
30.5
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Kaech, SM;Tan, JT;Ahmed, R
一个主要的未回答的问题是，如何区分急性病毒感染后死亡的大多数活化的CD 8 T细胞与存活成为长寿记忆细胞的小部分（5-10%）。在这项研究中，我们表明，白细胞介素7受体α链（IL-7 R α）的表达增加，识别效应CD 8 T细胞，将分化为记忆细胞。IL-7 R（hi）效应细胞含有增加量的抗凋亡分子，并且IL-7 R（hi）和IL-7 R（lo）效应细胞的过继转移表明IL-7 R（hi）细胞优先产生记忆细胞，其可以持续存在并赋予保护性免疫。因此，IL-7 R的选择性表达识别记忆细胞前体，并且该标记物可用于预测感染或免疫后产生的记忆T细胞的数量。
A major unanswered question is what distinguishes the majority of activated CD8 T cells that die after an acute viral infection from the small fraction (5-10%) that survive to become long-lived memory cells. In this study we show that increased expression of the interleukin 7 receptor alpha-chain (IL-7Ralpha) identifies the effector CD8 T cells that will differentiate into memory cells. IL-7R(hi) effector cells contained increased amounts of antiapoptotic molecules, and adoptive transfer of IL-7R(hi) and IL-7R(lo) effector cells showed that IL-7R(hi) cells preferentially gave rise to memory cells that could persist and confer protective immunity. Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization.