DIURNAL-VARIATION IN THE RESPONSE OF GAMMA-RAY-INDUCED APOPTOSIS IN THE MOUSE INTESTINAL EPITHELIUM
DIURNAL-VARIATION IN THE RESPONSE OF GAMMA-RAY-INDUCED APOPTOSIS IN THE MOUSE INTESTINAL EPITHELIUM
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DOI：
10.1016/0304-3835(83)90203-3
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发表时间：
1983-01-01
期刊：
影响因子：
9.7
通讯作者：
BLAKEY, DH
中科院分区：
文献类型：
--
作者：
DUNCAN, AMV;RONEN, A;BLAKEY, DH
细胞凋亡的出现已被用作肠上皮发生的致癌物诱导的损伤的指标。小鼠十二指肠和结肠上皮细胞中伽马辐射引起的细胞毒性反应明显受到动物接受辐射或采样的时间的影响。通过细胞凋亡的出现来测量隐窝细胞的放射敏感性的昼夜模式，反映了小鼠肠细胞的昼夜节律。因此，在解释仅在一个时间点获得的细胞凋亡数据或比较在一天中不同时间获得的数据时，应考虑昼夜节律的影响。
The appearance of apoptosis has been used as an index of carcinogen-induced damage incurred by the intestinal epithelium. The cytotoxic response elicited by gamma radiation in the duodenal and colonic epithelium of the mouse is markedly affected by the time of day at which the animals are irradiated or sampled. The diurnal pattern in radiosensitivity of the crypt cells, as measured by the appearance of apoptosis, is reflective of circadian rhythms in mouse intestinal cells. Circadian effects should therefore be considered when interpreting apoptosis data obtained at one time point only or when comparing data obtained at different times of the day.