The roles of the DAZ family in spermatogenesis: More than just translation?
The roles of the DAZ family in spermatogenesis: More than just translation?
复制标题
达兹家族在精子发生中的作用：不仅仅是翻译吗？
DOI：
10.4161/spmg.1.1.14659
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Xu EY
中科院分区：
文献类型：
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作者：
Vangompel MJ;Xu EY
DAZ基因家族是动物（包括人类）重要的生育因子。该家族由Y-连锁DAZ和常染色体同源物Boule和Dazl组成。所有这三个基因编码的RNA结合蛋白几乎只在生殖细胞中表达。DAZ家族是高度保守的，其祖先Boule通过人类存在于海葵中，Dazl在脊椎动物中保守，而DAZ仅存在于高等灵长类动物中。本文综述了DAZ家族基因在多种生物体中的研究进展，总结了DAZ家族基因的共同特征及其在动物精子发生中的作用。DAZ家族蛋白被认为激活RNA靶点的翻译，但最近的工作发现了其他功能。Boule，Dazl和DAZ可能通过类似的机制发挥作用，我们提出了DAZ家族在精子发生中的已知功能，并讨论了除了翻译激活之外的可能机制。
The DAZ family of genes are important fertility factors in animals, including humans. The family consists of Y-linked DAZ, and autosomal homologs Boule and Dazl. All three genes encode RNA-binding proteins that are nearly exclusively expressed in germ cells. The DAZ family is highly conserved, with ancestral Boule present in sea anemones through humans, Dazl conserved among vertebrates, and DAZ present only in higher primates. Here we review studies on DAZ family genes from multiple organisms, and summarize the common features of each DAZ gene and their roles during spermatogenesis in animals. DAZ family proteins are thought to activate the translation of RNA targets, but recent work has uncovered additional functions. Boule, Dazl, and DAZ likely function through similar mechanisms, and we present known functions of the DAZ family in spermatogenesis, and discuss possible mechanisms in addition to translation activation.