Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short-chain fatty acids and microbiota
Effects of total enteral nutrition supplemented with a multi-fibre mix on faecal short-chain fatty acids and microbiota
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DOI：
10.1016/j.clnu.2005.09.006
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发表时间：
2006-02-01
影响因子：
6.3
通讯作者：
Hébuterne, X
中科院分区：
文献类型：
--
作者：
Schneider, SM;Girard-Pipau, F;Hébuterne, X
背景和目的：管饲患者经常出现肠功能受损，腹泻与粪便短链脂肪酸 (SCFA) 浓度降低有关。本研究的目的是比较富含多种纤维的配方奶 (15 g/l) 和无纤维等能量等氮配方奶对长期肠内营养 (EN) 患者粪便 SCFA 和微生物群的影响。方法：15 名患者 [11M/4F，年龄 53 (40-73)] 因吞咽困难持续 43 (1-310) 个月接受总 EN 治疗。 7 天无纤维配方，然后以随机顺序使用 14 天富含多种纤维的配方，然后 14 天无纤维配方，反之亦然。每个时期结束时采集粪便样本，用于测量 SCFA 水平和不同细菌群。将结果与非参数测试进行比较。 结果：多纤维 EN 后，与基线相比，粪便 SCFA 总量 (+84%)、丁酸盐 (+20%) 和醋酸盐 (+147%) 中位数显着增加。通过分子方法测定发现，与无纤维 EN 期相比，多纤维 EN 期后细菌总数显着增加。肠道细菌的优势群体没有伴随变化。 结论：在长期 EN 患者中，添加六种纤维混合物的聚合肠内配方可增加粪便 SCFA 和细菌总数，这可能有助于改善肠道功能。 (c) 2005 年爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background and aims: Impaired bowel function is frequent in tube-fed patients, and diarrhoea is associated with decreased faecal short-chain fatty acids (SCFAs) concentrations. The aim of this study was to compare the effects of a multi-fibre-enriched formula (15 g/l) and a fibre-free isoenergetic and isonitrogenous formula on faecal SCFAs and microbiota in long-term enteral nutrition (EN) patients.Methods: Fifteen patients [11M/4F, aged 53 (40-73)] on total EN for 43 (1-310) months for dysphagia received a fibre-free formula for 7 days, followed in a random order by either the multi-fibre-enriched formula for 14 days and then the fibre-free formula for 14 days or vice versa. Stool samples were taken at the end of each period for measurement of SCFAs levels and different groups of bacteria. Results were compared with non-parametric tests.Results: After the multi fibre EN, there was a significant median increase in total faecal SCFAs (+84%), butyrate (+20%) and acetate (+147%) compared with baseline. A significant increase in the total number of bacteria as determined with the molecular method was found after the multi-fibre EN period compared with the fibre-free EN period. There were no concomitant changes in the dominant groups of intestinal bacteria.Conclusion: In long-term EN patients, a polymeric enteral formula supplemented with a mixture of six fibres increases faecal SCFAs and total number of bacteria, which may contribute to an improved bowel function. (c) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.