IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
复制标题
DOI：
10.1016/s1074-7613(00)80664-0
复制
发表时间：
1998-11-01
期刊：
影响因子：
32.4
通讯作者：
Ma, A
中科院分区：
文献类型：
--
作者：
Lodolce, JP;Boone, DL;Ma, A
IL-15受体α亚基（IL-15 R α）介导IL-15的高亲和力结合，IL-15是一种参与先天免疫细胞发育的多效性细胞因子。我们已经产生了IL-15 R α无效（IL-15 R α（-/-））小鼠，以了解IL-15 R α在免疫发育和功能中的作用。尽管T和B淋巴细胞发育大体正常，但IL-15 R α（-/-）小鼠淋巴细胞显著减少。这种淋巴细胞减少症是由于增殖减少和IL-15 R α（-/-）淋巴细胞归巢至外周淋巴结减少所致。这些小鼠也缺乏自然杀伤细胞、自然杀伤T细胞、CD 8（+）T淋巴细胞和TCR γ δ上皮内淋巴细胞。此外，记忆表型CD 8（+）T细胞的数量选择性减少。因此，IL-15 R α在免疫发育和功能中具有多效性作用，包括淋巴细胞稳态的积极维持。
The IL-15 receptor alpha subunit (IL-15R alpha) mediates high-affinity binding of IL-15, a pleiotropic cytokine implicated in the development of innate immune cells. We have generated IL-15R alpha null (IL-15R alpha(-/-)) mice to understand the role of IL-15R alpha in immune development and function. IL-15R alpha(-/-) mice are markedly lymphopenic despite grossly normal T and B lymphocyte development. This lymphopenia is due to decreased proliferation and decreased homing of IL-15R alpha(-/-) lymphocytes to peripheral lymph nodes. These mice are also deficient in natural killer cells, natural killer T cells, CD8(+) T lymphocytes, and TCR gamma delta intraepithelial lymphocytes. In addition, memory phenotype CD8(+) T cells are selectively reduced in number. Thus, IL-15R alpha has pleiotropic roles in immune development and function, including the positive maintenance of lymphocyte homeostasis.