Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces
Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces
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DOI：
10.1002/adfm.202112045
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发表时间：
2022-02-25
影响因子：
19
通讯作者：
Dayeh，Shadi A.
中科院分区：
文献类型：
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作者：
Lee，Sang Heon;Thunemann，Martin;Dayeh，Shadi A.
犹他州阵列为BrainGate等神经功能恢复的尖端项目提供动力，但基础电极技术本身在过去三十年中进展甚微。在这里，利用先进的双面光刻微细加工工艺来展示1024通道穿透硅微针阵列（SiMNA），其记录能力和皮质覆盖范围可扩展，适用于临床翻译。SiMNA是第一个具有柔性背衬的穿透性微针阵列，可顺应大脑运动。此外，SiMNA是光学透明的，允许同时进行神经元活动的光学和电生理询问。SiMNA用于证明对自发和诱发场电位的可靠记录，以及对长期植入小鼠中长达196天的单个单位活动的可靠记录，以响应光遗传学和胡须空气抽吸刺激。值得注意的是，1024通道SiMNA建立了大鼠宽带大脑活动的详细时空映射。这种新型的可扩展和生物相容的SiMNA具有多模态能力和对宽带大脑活动的敏感性，将加速基础神经生理学研究的进展，并为脑机接口的穿透和大面积覆盖微电极阵列建立新的里程碑。
The Utah array powers cutting‐edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in the last three decades. Here, advanced dual‐side lithographic microfabrication processes is exploited to demonstrate a 1024‐channel penetrating silicon microneedle array (SiMNA) that is scalable in its recording capabilities and cortical coverage and is suitable for clinical translation. The SiMNA is the first penetrating microneedle array with a flexible backing that affords compliancy to brain movements. In addition, the SiMNA is optically transparent permitting simultaneous optical and electrophysiological interrogation of neuronal activity. The SiMNA is used to demonstrate reliable recordings of spontaneous and evoked field potentials and of single unit activity in chronically implanted mice for up to 196 days in response to optogenetic and to whisker air‐puff stimuli. Significantly, the 1024‐channel SiMNA establishes detailed spatiotemporal mapping of broadband brain activity in rats. This novel scalable and biocompatible SiMNA with its multimodal capability and sensitivity to broadband brain activity will accelerate the progress in fundamental neurophysiological investigations and establishes a new milestone for penetrating and large area coverage microelectrode arrays for brain–machine interfaces.