GM1 gangliosidosis in friesian calves
GM1 gangliosidosis in friesian calves
复制标题
弗里斯兰犊牛 GM1 神经节苷脂沉积症
作者：
W. Donnelly;B. Sheahan;T. A. Rogers
Donnelly等人描述了来自两个牛群的四头Friesian牛犊的神经元脂肪堆积症的临床特征。(1972)。自那以后，从这些牛群中又发现了四头小牛犊患有这种疾病，并在总共七例病例中得到了组织化学的确认。在出生的第一个月就注意到了临床体征。受影响的小牛进食缓慢，迟钝，不愿移动和共济失调。疾病的发展导致昏迷和死亡，在6至9个月。组织病理学表现为脂肪样神经元肿胀。本文描述了其中7头小牛犊的形态和组织化学结果。文中还给出了三头患牛脑组织和一头对照牛脑组织的脂肪分析结果。
THE clinical features of a neuronal lipid storage disease in four Friesian calves from two herds have been described by Donnelly et al. (1972). The condition has since been recognised in four more calves from these herds and has been confirmed histochemically in a total of seven cases. Clinical signs were noticed in the first month of life. Affected calves were slow to feed, dull, reluctant to move and ataxic. Progression of the disease resulted in coma and death at 6 to 9 mth. Histopathological findings were ballooning of neurons with lipid. This paper describes the morphological and histochemical findings in seven of these calves. The results of lipid analyses of brain tissues from three affected calves and one control calf also are presented.