Moving bar of light evokes vectorial spatial selectivity in the immobile rat hippocampus.
Moving bar of light evokes vectorial spatial selectivity in the immobile rat hippocampus.
复制标题
移动的光条会引起不动的大鼠海马体的矢量空间选择性。
DOI：
10.1038/s41586-022-04404-x
复制
发表时间：
2022
期刊：
影响因子：
64.8
通讯作者：
Mehta,MayankR
中科院分区：
文献类型：
--
作者：
Purandare,ChinmayS;Dhingra,Shonali;Rios,Rodrigo;Vuong,Cliff;To,Thuc;Hachisuka,Ayaka;Choudhary,Krishna;Mehta,MayankR
视觉皮层神经元对特定刺激的位置和运动方向进行回溯性编码，而不需要任何运动或任务需求。作为视觉系统的一部分，海马被假设需要自我运动或认知任务来产生标量的、抽象的和前瞻性的空间选择性。在这里，我们测量了啮齿动物海马对身体固定大鼠的移动光条的选择性，以弥合这些看似的差异。大约70%的背侧CA1神经元表现出稳定的活动调制的角度位置的酒吧的功能，独立的行为和奖励。三分之一的调谐细胞也编码旋转的方向。在其他实验中，神经元编码的距离酒吧，与接近运动的偏好。总的来说，这些证明了视觉诱发向量选择性（VEVS）。与位置细胞不同，VEVS是回顾性的。视觉刺激或其可预测性的变化不会引起重新映射，而只会引起逐渐的变化。大多数VEVS调谐神经元在空间探索过程中表现出类似于位置细胞的行为，并且这两种选择性相关。因此，VEVS可以形成海马活动的基本构件。当与自我运动，奖励或多感官刺激相结合时，它可以产生包括allocentric空间，时间和情节的前瞻性表征的复杂性。
Visual cortical neurons encode the position and motion direction of specific stimuli retrospectively, without any locomotion or task demand. The hippocampus, which is a part of the visual system, is hypothesized to require self-motion or a cognitive task to generate allocentric spatial selectivity that is scalar, abstract,and prospective, , –. Here we measured rodent hippocampal selectivity to a moving bar of light in a body-fixed rat to bridge these seeming disparities. About 70% of dorsal CA1 neurons showed stable activity modulation as a function of the angular position of the bar, independent of behaviour and rewards. One-third of tuned cells also encoded the direction of revolution. In other experiments, neurons encoded the distance of the bar, with preference for approaching motion. Collectively, these demonstrate visually evoked vectorial selectivity (VEVS). Unlike place cells, VEVS was retrospective. Changes in the visual stimulus or its predictability did not cause remapping but only caused gradual changes. Most VEVS-tuned neurons behaved like place cells during spatial exploration and the two selectivities were correlated. Thus, VEVS could form the basic building block of hippocampal activity. When combined with self-motion, reward or multisensory stimuli, it can generate the complexity of prospective representations including allocentric space, time,and episodes.