Alzheimer disease and frontotemporal dementias - Behavioral distinctions
Alzheimer disease and frontotemporal dementias - Behavioral distinctions
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DOI：
10.1001/archneur.1996.00550070129021
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发表时间：
1996-07-01
影响因子：
--
通讯作者：
Craig, A
中科院分区：
文献类型：
--
作者：
Levy, ML;Miller, BL;Craig, A
背景资料：额颞叶痴呆（FTD）是一种综合征所产生的叶变性的颞叶和/或额叶。Objectives：量化的行为障碍的FTD和比较他们观察到的行为变化在阿尔茨海默病（AD）。设计：横断面比较2组定义的研究诊断标准和单光子发射计算机断层扫描。行为评估采用标准化的评定量表-神经精神量表。组进行匹配的痴呆severity.Setting：患者被认为是在2所大学为基础的痴呆症门诊诊所和退伍军人事务部medical center.Participants：22例FTD和30例AD患者。结果：FTD患者有显着更大的总神经精神量表评分比AD患者，表现出更多的冷漠，去抑制，欣快，和异常的运动行为。神经精神量表使用去抑制、冷漠和抑郁准确地将77%的FTD患者和77%的AD患者分配到正确的诊断组。与AD患者相比，FTD患者有较高水平的去抑制和冷漠，抑郁水平相对较低。结论：神经精神量表提供了一个行为特征，区分FTD患者与AD患者。FTD患者的行为障碍更多，但相对于冷漠水平，抑郁程度通常低于AD患者。
Background: Frontotemporal dementia (FTD) is a syndrome produced by lobar degeneration of the temporal and/or frontal lobes.Objectives: To quantify the behavioral disturbances of FTD and compare them with behavioral changes observed in Alzheimer disease (AD).Design: Cross-sectional comparison of 2 groups defined by research diagnostic criteria and single photon emission computed tomography. Behaviors were assessed using a standardized rating scale-Neuropsychiatric Inventory. Groups were matched for dementia severity.Setting: Patients were seen at 2 university-based outpatient dementia clinics and a Veterans Affairs medical center.Participants: Twenty-two patients with FTD and 30 patients with AD.Results: Patients with FTD had significantly greater total Neuropsychiatric Inventory scores than patients with AD and exhibited more apathy, disinhibition, euphoria, and aberrant motor behavior. The Neuropsychiatric Inventory accurately assigned 77% of patients with FTD and 77% of patients with AD to the correct diagnostic group using disinhibition, apathy, and depression. Patients with FTD had higher levels of disinhibition and apathy with relatively lower levels of depression compared with patients with AD.Conclusions: The Neuropsychiatric Inventory provides a behavioral profile that differentiates patients with FTD from patients with AD. Patients with FTD are more behaviorally disturbed but are often less depressed than patients with AD relative to their level of apathy.