Pretreatment serum C-reactive protein is a significant prognostic factor in patients with soft tissue metastases
Pretreatment serum C-reactive protein is a significant prognostic factor in patients with soft tissue metastases
复制标题
DOI：
10.1016/j.jos.2020.04.017
复制
发表时间：
2021-05-06
影响因子：
1.7
通讯作者：
Tanaka, Sakae
中科院分区：
文献类型：
--
作者：
Ishibashi, Yuki;Kobayashi, Hiroshi;Tanaka, Sakae
背景：软组织转移比骨转移罕见。软组织转移的患者通常预后较差。转移灶的治疗有时很困难，因为软组织转移患者的预后因素仍不清楚。因此，本研究旨在确定这些预后因素。方法：本研究纳入31例软组织转移患者。我们使用 Kaplan-Meier 曲线和 Cox 比例风险模型评估了总体生存率与临床参数和炎症标志物的关联。结果：12 例患者接受了软组织转移手术，6 例患者接受了放射治疗。检测到软组织转移后的中位总生存期为 11 个月。单因素分析显示，多学科治疗后检测到软组织转移（P=0.01）；孤立性转移（P = 0.0003）；治疗前C反应蛋白（CRP）水平<0.4mg/dL（P<0.0001）、白细胞计数<8500×10（3）/μL（P=0.0003）和中性粒细胞与淋巴细胞比率<5（P=0.02）是显着的良好预后因素。多变量分析显示，CRP 值 < 0.4 mg/dL (P = 0.07) 和孤立性转移 (P = 0.09) 可能是生存的重要预测因素。此外，如果 CRP 水平
Background: Soft tissue metastasis is rarer than bone metastasis. Patients with soft tissue metastasis generally have a dismal prognosis. The treatment for metastatic lesions is sometimes difficult, because the prognostic factors of patients with soft tissue metastasis remain unelucidated. Therefore, this study aimed to identify these prognostic factors.Methods: Thirty-one patients with soft tissue metastasis were included in the study. We evaluated associations of overall survival with clinical parameters and inflammatory markers using Kaplan-Meier curves and Cox proportional hazards models.Results: Twelve patients received surgery for soft tissue metastasis, while radiation therapy was performed in six cases. The median overall survival after the detection of soft tissue metastasis was 11 months. Univariate analysis revealed that detection of soft tissue metastasis after the multidisciplinary treatment (P = 0.01); solitary metastasis (P = 0.0003); and pretreatment C-reactive protein (CRP) level < 0.4 mg/dL (P < 0.0001), white blood cell count < 8500 x 10(3)/mu L (P = 0.0003), and neutrophil-tolymphocyte ratio < 5 (P = 0.02) were significant good prognostic factors. Multivariate analysis revealed that a CRP value < 0.4 mg/dL (P = 0.07) and solitary metastasis (P = 0.09) were possible significant predictors of survival. Furthermore, in case of CRP levels