SUPPRESSION OF C-JUN AP-1 ACTIVATION BY AN INHIBITOR OF TUMOR PROMOTION IN MOUSE FIBROBLAST CELLS
SUPPRESSION OF C-JUN AP-1 ACTIVATION BY AN INHIBITOR OF TUMOR PROMOTION IN MOUSE FIBROBLAST CELLS
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DOI：
10.1073/pnas.88.12.5292
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发表时间：
1991-06-01
影响因子：
11.1
通讯作者：
LIN, JK
中科院分区：
文献类型：
--
作者：
HUANG, TS;LEE, SC;LIN, JK
姜黄素，一种膳食色素，负责咖喱的黄色，是一种有效的抑制剂，促进肿瘤的phobol酯。转录因子c-Jun/AP-1的功能激活被认为在phorbol 12-肉豆蔻酸酯13-乙酸酯诱导的促肿瘤信号转导中起重要作用。在小鼠成纤维细胞中观察到姜黄素抑制c-Jun/AP-1的激活。体外实验表明，姜黄素抑制c-Jun/AP-1与其同源基序的结合可能是抑制c-Jun/AP-1介导的基因表达的原因。这些结果表明，姜黄素对12-肉豆蔻酸13-醋酸酯诱导的炎症/肿瘤促进作用可以在分子水平上进行研究。
Curcumin, a dietary pigment responsible for the yellow color of curry, is a potent inhibitor of tumor promotion by phorbol esters. Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion. Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells. In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression. These findings show that the effect of curcumin on phorbol 12-myristate 13-acetate-induced inflammation/tumor promotion could be studied at the molecular level.