INFLUENCE OF CASTRATION, ALONE OR COMBINED WITH THYMECTOMY, ON THE DEVELOPMENT OF DIABETES IN THE NONOBESE DIABETIC MOUSE
INFLUENCE OF CASTRATION, ALONE OR COMBINED WITH THYMECTOMY, ON THE DEVELOPMENT OF DIABETES IN THE NONOBESE DIABETIC MOUSE
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DOI：
10.1210/endo-129-3-1382
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发表时间：
1991-09-01
期刊：
影响因子：
4.8
通讯作者：
DARDENNE, M
中科院分区：
文献类型：
--
作者：
FITZPATRICK, F;LEPAULT, F;DARDENNE, M
非肥胖糖尿病（NOD）小鼠是公认的研究免疫介导的胰岛素依赖型糖尿病的模型。 这种疾病在女性中的发病率似乎高于男性。 断奶时阉割导致NOD男性糖尿病患病率显著增加，而NOD女性糖尿病患病率则呈下降趋势。 去势结合胸腺切除术被发现进一步增加糖尿病的患病率在NOD男性，而在女性去势逆转胸腺切除术的效果。 这些糖尿病患病率变化的结果被指向胰岛的淋巴细胞浸润程度所证实。 总之，这些结果表明，内分泌和免疫系统之间的直接关系，从而椎间盘切除术对糖尿病的免疫发病机制有有害影响。 此外，我们还研究了淋巴细胞亚群的分布、有丝分裂原反应性、淋巴因子产生和对胸腺依赖性抗原（如绵羊红细胞）的体内反应是否依赖或独立于性类固醇环境。
The nonobese diabetic (NOD) mouse is a recognized model for studying immunologically-mediated insulin-dependent diabetes mellitus. The disease appears with a greater preponderance in females than in males. Castration at weaning led to a significant increase in the prevalence of diabetes in NOD males, whereas a tendency to a decreased prevalence was observed in NOD females. Castration combined with thymectomy was found to further increase the prevalence of diabetes in NOD males, whereas in females castration reversed the effect of thymectomy. These results on changes in diabetes prevalence were corroborated by the degree of lymphocytic infiltration directed toward the pancreatic islets of Langerhans. Taken together these results indicate a direct relationship between the endocrine and immune systems, whereby orchidectomy has a deleterious effect on the immunopathogenesis of diabetes. In addition, we examined whether the distribution of lymphocyte subpopulations, mitogen reactivity, lymphokine production, and in vivo response to a thymus-dependent antigen, such as sheep red blood cell, were dependent or independent of the sex steroid environment.