Epilepsy and Synaptic Reorganization in a Perinatal Rat Model of Hypoxia–Ischemia

Epilepsy and Synaptic Reorganization in a Perinatal Rat Model of Hypoxia–Ischemia
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DOI:
10.1111/j.0013-9580.2004.60403.x
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发表时间:
2004-10
期刊:
影响因子:
5.6
通讯作者:
P. Williams;P. Dou;F. Dudek
P. Williams;P. Dou;F. Dudek
中科院分区:
医学1区
文献类型:
--
作者:
P. Williams;P. Dou;F. Dudek

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Summary: Purpose: One of the potential consequences of perinatal hypoxia–ischemia (H‐I) is the development of epilepsy, and synaptic reorganization in the hippocampus has been associated with epilepsy after an injury. We tested the hypothesis that perinatal H‐I will induce spontaneous motor seizures, hippocampal lesions, and synaptic reorganization in the dentate gyrus.