A HUMAN CHROMOSOME-8 REGION WITH ABNORMALITIES IN B-CELL, HTLV-I+ T-CELL AND C-MYC AMPLIFIED TUMORS
A HUMAN CHROMOSOME-8 REGION WITH ABNORMALITIES IN B-CELL, HTLV-I+ T-CELL AND C-MYC AMPLIFIED TUMORS
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DOI：
10.1002/j.1460-2075.1987.tb02458.x
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发表时间：
1987-07-01
期刊：
影响因子：
11.4
通讯作者：
RABBITTS, TH
中科院分区：
文献类型：
--
作者：
MENGLEGAW, L;RABBITTS, TH
我们描述了人类染色体8 q24的一个区域，该区域参与了变异型伯基特淋巴瘤易位，并且在HTLV-I+ ATL中发生了间质缺失，并且三个c-myc扩增子终止。ATL DNA中的缺失开始于克隆的伯基特淋巴瘤翻译断裂点的1.3 kb内，结束于克隆的相当于大鼠逆转录病毒插入位点mis-1的人的700个碱基内。此外，三个c-myc扩增子终止于该区域，其中一个（结肠癌/COL 0320）的末端位于ATL缺失远端的12 kb内。该区域可能在c-myc下游约300 kb处，并且在该区域中异常的一致发生暗示了在几种不同细胞类型中涉及肿瘤病因学。
We describe a region of human chromosome 8q24 involved in variant Burkitt''s lymphoma translocations, and where an interstitial deletion occurs in an HTLV-I+ ATL and three c-myc amplicons terminate. The deletion in the ATL DNA begins within 1.3 kb of the cloned Burkitt''s lymphoma translation breakpoint and ends within 700 bases of the cloned human equivalent of the rat retroviral insertion site, mis-1. In addition, three c-myc amplicons terminate in this region and the end of one of these (the colon carcinoma/COL0320) maps within 12 kb of the distal end of the ATL deletion. This region is probably .apprx.300 kb downstream of c-myc and the consistent occurrence of abnormalities in this region implies involvement in tumour aetiology in several different cell types.