Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea
Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea
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DOI：
10.1111/j.1447-0756.2008.00802.x
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发表时间：
2008-12-01
影响因子：
1.6
通讯作者：
Yurekli, Muhuttin
中科院分区：
文献类型：
--
作者：
Dikensoy, Ebru;Balat, Ozcan;Yurekli, Muhuttin
目的：本研究的目的是研究年轻女性原发性痛经与血清丙二醛（MDA）、一氧化氮（NO）和肾上腺髓质素（AM）水平之间是否存在关系。方法：60名无严重健康问题的女性受试者，年龄在20至34岁之间，至少有6个月经周期。每个患者在月经周期的第1天和第21天采集血样。进行盆腔检查和超声检查以确定每位患者痛经的器质性原因。受试者被分成两组。研究组为原发性痛经患者30例，对照组为健康者30例。结果：两组间年龄、胎次、体重指数比较差异无统计学意义。实验组第1天血清MDA、NO、AM水平显著高于第21天（P < 0.05）。在月经周期第1天和第21天，研究组血清MDA、NO、AM水平均显著高于对照组（P < 0.05）。结论：综上所述，本研究结果显示原发性痛经患者血清MDA、NO、AM水平升高，提示脂质过氧化和氧化应激可能在原发性痛经的发病机制中起重要作用。
Aim: The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women.Methods: Sixty female subjects without serious medical problems, aged between 20 and 34, who had regular menses for at least six previous cycles, were involved. Blood samples were obtained from each patient on the first and the 21st days of her menstrual cycles. Pelvic examination and ultrasound were performed to determine any organic cause for dysmenorrhea in each patient. The subjects were divided into two groups. The study group consisted of 30 subjects with primary dysmenorrhea, and the control group consisted of 30 healthy subjects.Results: No statistically significant difference was observed in comparison of the following variables between the groups: age, parity and body mass index. The serum levels of MDA, NO, and AM were significantly higher on the first day compared to those on the 21(st) day in the study group (P < 0.05). The serum levels of MDA, NO, and AM were significantly higher in the study group compared to the control group both on the first and the 21st days of the menstrual cycles (P < 0.05).Conclusion: In conclusion, the results of this study showed that the serum levels of MDA, NO, and AM increase in subjects with primary dysmenorrhea, suggesting the possibility that lipid peroxidation and oxidative stress play a significant role in the etiopathogenesis of primary dysmenorrhea.