IMMUNOLOGICAL ASPECTS OF ACUTE URETERAL OBSTRUCTION - IMMUNE CELL INFILTRATE IN THE KIDNEY
IMMUNOLOGICAL ASPECTS OF ACUTE URETERAL OBSTRUCTION - IMMUNE CELL INFILTRATE IN THE KIDNEY
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DOI：
10.1038/ki.1988.207
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发表时间：
1988-10-01
影响因子：
19.6
通讯作者：
KLAHR, S
中科院分区：
文献类型：
--
作者：
SCHREINER, GF;HARRIS, KPG;KLAHR, S
分析了双侧输尿管梗阻（BUO）、单侧输尿管梗阻（UUO）和UUO随后释放的大鼠肾脏的白细胞浸润。白细胞，主要是巨噬细胞和抑制性T淋巴细胞的时间依赖性流入，发生在皮质和髓质阻塞后，并消失与释放的阻塞。肾小球巨噬细胞在梗阻后下降，但在释放后增加至高于对照组的水平。阻塞后白细胞的流入被肾脏血栓素B2排泄的增加所抑制，并与肾小球滤过率（GFR）的降低相一致。这表明免疫细胞的流入是输尿管梗阻急性肾反应的一个显著特征。这些细胞可能通过产生血管活性物质（如血栓素A2）来调节肾功能的一些梗阻后改变。
Kidneys from rats subjected to bilateral ureteral obstruction (BUO), unilateral ureteral obstruction (UUO) and UUO with subsequent release were analyzed for leukocyte infiltration. A time-dependent influx of leukocytes, predominantly macrophages and suppressor T lymphocytes, occurred in both the cortex and medulla following obstruction, and disappeared with release of the obstruction. Glomerular macrophages declined following obstruction but increased to levels above control following release. The influx of leukocytes following obstruction was paralleled by an increase in thromboxane B2 excretion by the kidney and coincided with a decrease in glomerular filtration rate (GFR). This would suggest that an influx of immune cells is a prominent feature of the acute renal response to ureteral obstruction. These cells may modulate some of the post-obstructive alterations in renal function via the production of vasoactive substances, such as thromboxane A2.