2,3-Dideoxyglucosides of selected terpene phenols and alcohols as potent antifungal compounds
2,3-Dideoxyglucosides of selected terpene phenols and alcohols as potent antifungal compounds
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DOI：
10.1016/j.foodchem.2016.04.127
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发表时间：
2016-11-01
期刊：
影响因子：
8.8
通讯作者：
Srinivas, P.
中科院分区：
文献类型：
--
作者：
Bound, D. James;Murthy, Pushpa S.;Srinivas, P.
测试了香芹酚、百里香酚和紫苏醇的新型 2,3-不饱和和 2,3-二脱氧 1-O-葡萄糖苷对黄曲霉、赭曲霉、尖镰孢、酿酒酵母和白色念珠菌的抗真菌活性。在琼脂井扩散试验中，香芹酚、百里香酚和紫苏醇衍生物对于丝状真菌的抑制区比母体化合物的抑制区更高（15-30毫米）。其 MIC 和 MFC 值表明香芹酚和百里香酚的 2,3-不饱和和 2,3-二脱氧 1-O-葡萄糖苷比其他化合物表现出更强的杀菌活性。此外，香芹酚和百里香酚的2,3-二脱氧葡萄糖苷对赭曲霉和黄曲霉表现出抗毒素作用，并抑制赭曲霉毒素和黄曲霉毒素-B2的产生。碘化丙啶流入测定证明了香芹酚及其 2,3-不饱和 1-O-葡萄糖苷对白色念珠菌细胞的裂解以及膜完整性的丧失。这些新的 2,3-二脱氧葡萄糖苷可用作食品中的抗真菌剂和调味品。 (C) 2016 Elsevier Ltd. 保留所有权利。
The antifungal activities of novel 2,3-unsaturated and 2,3-dideoxy 1-O-glucosides of carvacrol, thymol, and perillyl alcohol were tested against Aspergillus flavus, Aspergillus ochraceus, Fusarium oxysporum, Saccharomyces cerevisiae and Candida albicans. In the agar well diffusion tests, zones of inhibition for the derivatives of carvacrol, thymol and perillyl alcohol were higher (15-30 mm) in the case of filamentous fungi than those for the parent compounds. Their MIC and MFC values indicated that the 2,3-unsaturated and 2,3-dideoxy 1-O-glucosides of carvacrol and thymol exhibited more fungicidal activity than the other compounds. Further, the 2,3-dideoxyglucosides of carvacrol and thymol, exhibited antitoxigenic effects against A. ochraceus and A. flavus and inhibited the production of ochratoxin and aflatoxin-B2. Propidium iodide influx assay demonstrated the lysis of C. albicans cells by carvacrol and its 2,3-unsaturated 1-O-glucoside and the loss of the membrane integrity. These new 2,3-dideoxyglucosides can be useful as antifungal agents and condiments in foods. (C) 2016 Elsevier Ltd. All rights reserved.