Ruthenium-catalyzed cyclization of 2-alkyl-1-ethynylbenzenes via a 1,5-hydrogen shift of ruthenium-vinylidene intermediates
Ruthenium-catalyzed cyclization of 2-alkyl-1-ethynylbenzenes via a 1,5-hydrogen shift of ruthenium-vinylidene intermediates
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DOI：
10.1021/jo062573l
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发表时间：
2007-04-27
影响因子：
3.6
通讯作者：
Liu, Rai-Shung
中科院分区：
文献类型：
--
作者：
Odedra, Arjan;Datta, Swarup;Liu, Rai-Shung
Catalytic cyclization of 2-alkyl-1-ethynylbenzene derivatives was implemented by TpRuPPh(3)(CH3CN)(2)PF6 (10 mol %) in hot toluene (105 degrees C, 36-100 h) to form 1-substituted-1H-indene and 1-indanone products; such cyclizations proceeded more efficiently for substrates bearing electron-rich benzenes. We propose that the cyclization mechanism involves a 1,5-hydrogen shift of initial metal-vinylidene intermediate.
