Intake of cruciferous vegetables modifies bladder cancer survival.
Intake of cruciferous vegetables modifies bladder cancer survival.
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DOI：
10.1158/1055-9965.epi-10-0008
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
McCann SE
中科院分区：
文献类型：
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作者：
Tang L;Zirpoli GR;Guru K;Moysich KB;Zhang Y;Ambrosone CB;McCann SE
十字花科蔬菜是饮食中异硫氰酸酯的丰富来源，其摄入量与膀胱癌的风险呈负相关。由于饮食中的异硫氰酸酯在体外和体内模型中对膀胱癌具有有效的抗增殖作用，十字花科蔬菜的摄入也可能在膀胱癌患者的生存中发挥作用。利用从Roswell Park癌症研究所肿瘤登记处获得的信息、患者医疗记录和常规收集的问卷数据，我们研究了十字花科蔬菜摄入量与膀胱癌患者生存之间的潜在联系。由于烹饪可以大大减少或破坏异硫氰酸酯，因此对生十字花科蔬菜和熟十字花科蔬菜的消费分别进行了研究。使用Cox比例风险模型估计风险比（HR）和95%置信区间（CI）。共有239名膀胱癌患者参与了这项研究。在平均8年的随访后，179人死亡，其中101人死于膀胱癌。在对其他预后因素进行校正后，膀胱癌死亡率与西兰花摄入量之间存在强烈且显著的负相关，特别是生西兰花摄入量（每月≥1份vs < 1份）；总死亡的HR为0.57；95% CI为0.39-0.83；疾病特异性死亡的HR为0.43；95% CI为0.25-0.74)。蔬菜总量、水果总量或其他十字花科蔬菜没有显著的相关性。考虑到强有力的临床前证据，摄入西兰花可能会提高膀胱癌的存活率。需要进一步的前瞻性研究来证实十字花科蔬菜在膀胱癌预后中的潜在作用。
Intake of cruciferous vegetables, a rich source of dietary isothiocyanates, has been inversely associated with risk of bladder cancer. Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in both in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer. Utilizing information obtained from the Roswell Park Cancer Institute Tumor Registry, patient medical records, and routinely-collected questionnaire data, we examined potential associations between intake of cruciferous vegetables and survival among bladder cancer patients. As cooking can substantially reduce or destroy isothiocyanates, consumption of raw versus cooked cruciferous vegetables was examined separately. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard models. A total of 239 bladder cancer patients were included in the study. After an average of 8 years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake (≥ 1 versus < 1 serving per month; HR for overall death, 0.57; 95% CI, 0.39–0.83; HR for disease-specific death, 0.43; 95% CI, 0.25–0.74). There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables. Considering the strong preclinical evidence, intake of broccoli may improve bladder cancer survival. Further prospective investigation is warranted to confirm the potential role of cruciferous vegetables in bladder cancer prognosis.