Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation.
Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation.
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DOI：
10.1111/bjh.14830
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发表时间：
2017-09
影响因子：
6.5
通讯作者：
Gertz MA
中科院分区：
文献类型：
--
作者：
Muchtar E;Dispenzieri A;Lacy MQ;Buadi FK;Kapoor P;Hayman SR;Gonsalves W;Warsame R;Kourelis TV;Chakraborty R;Russell S;Lust JA;Lin Y;Go RS;Zeldenrust S;Dingli D;Leung N;Rajkumar SV;Kyle RA;Kumar SK;Gertz MA
血清乳酸脱氢酶（LDH）在轻链（AL）淀粉样变性中的意义以前尚未探讨。我们研究了1019例新诊断的患者，并将LDH升高超过正常上限（ULN）与疾病特征和结局相关。409例患者的LDH高于ULN，占研究人群的40%。与LDH正常的患者相比，LDH升高的患者年龄更大，男性的可能性更小，器官受累更广泛。高LDH患者心、肾功能损害更严重。LDH升高是总生存率和诊断后6个月内死亡的独立预后指标，但仅限于不适合干细胞移植的患者。血清LDH可作为器官损伤的标志物，并应探索作为组织愈合和器官恢复的潜在标志物。
The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 month of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.
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全身性淀粉样变性的临床特征和结果：231例中国患者的队列。
影响因子：
4.6
作者：
Huang X;Wang Q;Jiang S;Chen W;Zeng C;Liu Z
通讯作者：
Liu Z
影响因子：
45.3
作者：
Kourelis, Taxiarchis V.;Kumar, Shaji K.;Dispenzieri, Angela
通讯作者：
Dispenzieri, Angela
影响因子：
20.3
作者：
Muchtar, Eli;Gertz, Morie A.;Dispenzieri, Angela
通讯作者：
Dispenzieri, Angela
影响因子：
2.7
作者：
Gkotzamanidou, Maria;Kastritis, Efstathios;Dimopoulos, Meletios A.
通讯作者：
Dimopoulos, Meletios A.
影响因子：
3.5
作者：
Walenta, S;Mueller-Klieser, WF
通讯作者：
Mueller-Klieser, WF