Bone regeneration in segmental defects with resorbable polymeric membranes:: IV.: Does the polymer chemical composition affect the healing process?
Bone regeneration in segmental defects with resorbable polymeric membranes:: IV.: Does the polymer chemical composition affect the healing process?
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DOI：
10.1016/s0142-9612(00)00119-8
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
B端sing, CM
中科院分区：
文献类型：
--
作者：
Gogolewski, S;Pineda, L;B端sing, CM
用聚（L/D-丙交酯）（18只）和聚（L/DL-丙交酯）（18只）制备的管状微孔膜覆盖36只成年家兔桡骨10 mm长的骨干节段性缺损，以确定膜的化学成分是否影响缺损中的骨愈合。将先前研究的结果作为对照，在该研究中，未用膜覆盖或用聚（L-丙交酯）膜覆盖兔桡骨的类似缺损。对照组缺损迅速填充上覆的肌肉和软组织，形成桡尺骨性结合。对照缺损的骨活动仅限于骨端。膜覆盖的缺损逐渐被新骨填充。在1年时，在16例病例中发现了聚（L/D-丙交酯）膜覆盖的缺损处的完全骨再生，1只动物无再生，1只动物出现假关节。对于聚（L/DL-丙交酯）膜，有17例完全骨再生（1只动物在手术期间死亡）。新骨和膜之间的界面质量似乎受到用于膜制备的聚乳酸的化学结构的影响。对于聚（L/D-丙交酯），结缔组织层将新骨与聚合物膜完全分离。这在聚（L-丙交酯）膜之前已经观察到。在聚（L/DL-丙交酯）的情况下，在与膜直接接触的一些位置形成新骨，并且膜碎片被骨整合。聚乳酸膜的化学组成的差异对兔桡骨节段性缺损的骨再生过程没有明显影响。(C)2000爱思唯尔科技有限公司版权所有。
Diaphyseal segmental defects 10 mm in length in the radii of 36 skeletally mature rabbits were covered with tubular microporous membranes prepared from poly(L/D-lactide) (18 rabbits) and poly(L/DL-lactide) (18 rabbits) to determine whether chemical composition of the membrane affected the bone healing in the defect. The results of a previous study in which similar defects of the rabbits radii were not covered with membranes or covered with poly(L-lactide) membranes were used as controls. The control defects were rapidly filled with overlying muscle and soft tissues, producing a radio-ulnar synostosis. The osseous activity of control defects was limited to the bone ends. The defects covered with membranes were progressively filled with new bone. At 1 year, complete bone regeneration in the defects covered with the poly(L/D-lactide) membrane was found in 16 cases, no regeneration in 1 animal and pseudoarthrosis in 1 animal. For the poly(L/DL-lactide) membrane there was complete bone regeneration in 17 cases (1 animal died during surgery). The quality of the interface between the new bone and the membrane seemed to be affected by the chemical structure of the polylactides used for membranes preparation. For poly(L/D-lactide), the connective tissue layer entirely separated the new bone from the polymeric membrane. This has been observed before for poly(L-lactide) membranes. In the case of poly(L/DL-lactide) the new bone was formed in some places in direct contact with the membrane and the membrane fragments were osteointegrated. The differences in chemical composition of the polylactide membranes did not have an evident effect on the bone regeneration process in segmental defects of the rabbit radii. (C) 2000 Elsevier Science Ltd. All rights reserved.