XY sex-reversal syndrome in the domestic horse.
XY sex-reversal syndrome in the domestic horse.
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家养马的 XY 性逆转综合症。
DOI：
10.1159/000132243
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Weber,AF
中科院分区：
文献类型：
--
作者：
Kent,MG;Shoffner,RN;Buoen,L;Weber,AF
XY性别反转综合症发生在母马出生时，它的核型与种马相同。该综合征表现为基因型和表型异质性。性别逆转的遗传状况经常发生在某些谱系中，其中XY女性已经被发现，并且可以很容易地通过染色体核型检测到。表型范围从生殖道正常的雌性母马到高度雄性化的母马。家谱分析表明，有两种遗传模式：(1)x连锁隐性遗传或常染色体性别限制性显性遗传通过女性传播；(2)常染色体性别限制性显性遗传或Y染色体变异表达通过男性传播。
The XY sex-reversal syndrome occurs when a phenotypic mare is born that has the karyotype of a stallion. The syndrome is manifested by both genotypic and phenotypic heterogeneity. The sex-reversed genetic condition occurs frequently within certain pedigrees where XY females have been found and can be readily detected by chromosome karyotyping. The phenotypic spectrum ranges from the feminine mare with a reproductive tract that is within normal limits to the greatly masculinized mare. Pedigree analysis suggests that there are two modes of inheritance: (1) an X-linked recessive or autosomal sex-limited dominant transmitted through the female and (2) an autosomal sex-limited dominant or a Y chromosomal mutation with variable expression transmitted through the male.