Environmental Fate of Polyhexamethylene Biguanide
Environmental Fate of Polyhexamethylene Biguanide
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DOI：
10.1007/s00128-011-0436-3
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发表时间：
2012-03-01
影响因子：
2.7
通讯作者：
Lucas, Anne D.
中科院分区：
文献类型：
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作者：
Lucas, Anne D.
聚双胍（PHMB）在从医疗器械到游泳池的各种应用中用作杀菌剂，但对某些水生物种具有高度毒性。考察了PHMB在各种环境基质中的稳定性。20天后，80%的PHMB存在于强化的小溪样品中，但立即与土壤结合，桑迪土壤除外。PHMB在12 h内被风化混凝土吸收至低于可检测水平。此外，评价了一种含有PHMB的非处方伤口护理产品，以评估环境浸出; 1周后仍存在可检测水平（20 μ g/mL）。
Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the exception of sandy soil. PHMB was absorbed to below detectable levels by weathered concrete within 12 h. In addition, one over the counter wound care product containing PHMB was evaluated to assess environmental leaching; detectable levels (20 mu g/mL) were still present after 1 week.