The oxytocinase subfamily of M1 aminopeptidases
The oxytocinase subfamily of M1 aminopeptidases
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DOI：
10.1016/j.bbapap.2004.09.011
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发表时间：
2005-08-01
影响因子：
3.2
通讯作者：
Hattori, A
中科院分区：
文献类型：
--
作者：
Tsujimoto, M;Hattori, A
胎盘亮氨酸氨基肽酶(P-LAP)、脂肪细胞衍生的亮氨酸氨基肽酶(A-LAP)和白细胞衍生的氨基肽酶(L-RAP)属于氨基肽酶的M I家族中的一个不同的家族，它们都有HEXXH(X)(X)(18)E锌结合和GAAME基序，是酶活性所必需的。细胞内定位是亚家族成员的特征。当P-LAP以刺激依赖的方式从细胞内囊泡转运到质膜时，A-LAP和L-RAP都保留在内质网中。它们包含在细胞中进行特定定位所需的序列。越来越明显的是，亚家族成员在维持体内平衡方面发挥着重要作用，包括维持正常妊娠、记忆保持、血压调节和抗原递呈。本文对这个新发现的亚家族的研究现状进行了综述。(C)2004爱思唯尔B.V.保留所有权利。
The placental leucine aminopeptidase (P-LAP), adipocyte-derived leucine aminopeptidase (A-LAP) and leukocyte-derived aminopeptidase (L-RAP) belong to one distinct group of the M I family of amimopeptidases, which we term the "Oxytocinase subfamily", They share HEXXH(X)(18)E Zn-binding and GAMEN motifs essential for the enzymatic activities. Intracellular localization is the characteristic feature of the subfamily members. While P-LAP is translocated from intracellular vesicles to plasma membrane in a stimulus-dependent manner, both A-LAP and L-RAP are retained in the endoplasmic reticulum. They contain sequences necessary for the specific localization in the cell. It is getting evident that the subfamily members play important roles in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. In this review, current situation of this newly identified subfamily is summarized. (c) 2004 Elsevier B.V. All rights reserved.