Characteristics of Environmental influences on Child Health Outcomes (ECHO) Cohorts Recruited During Pregnancy.
Characteristics of Environmental influences on Child Health Outcomes (ECHO) Cohorts Recruited During Pregnancy.
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DOI：
10.1097/nmc.0000000000000725
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发表时间：
2021-07-01
期刊：
影响因子：
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通讯作者：
Huddleston KC
中科院分区：
文献类型：
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作者：
Faro EZ;Sauder KA;Anderson AL;Dunlop AL;Kerver JM;McGrath M;Roary M;Roman CW;Weidinger C;Huddleston KC
本研究的目的是描述研究设计、招募策略和妊娠期间启动的队列的其他研究特征，作为环境对儿童健康结局影响（ECHO）计划的一部分。对ECHO研究计划（队列）进行了审查。2018年，只有那些在怀孕期间进行过或目前正在进行招募的人接受了关于研究招募策略（参与者激励，学习负担，社区合作和文化适应）的调查。数据与队列特征（位置、入选和排除标准、社会人口统计学、医学信息、行为因素和生物标本）一起呈现。84个ECHO儿科队列中的47个在妊娠期间招募。研究结果表明，各种招募策略，数据收集和生物标本收集的领域都是成功的队列的特征。这些数据包括来自全国各地家庭的50，000多名儿童，其中许多人在服务不足的地区，将用于可能导致深刻政策变化的研究。可以利用包括生物标志物在内的研究数据，从怀孕到分娩，一直到儿童期，审查关于产前条件，如产妇年龄、肥胖、抑郁和吸毒的政策，这将为关于生命早期暴露的作用和疾病进展的基本机制的国家政策提供信息。
The objective of this study was to characterize the study designs, recruitment strategies, and other study characteristics among cohorts that initiated during pregnancy as part of the Environmental influences on Child Health Outcomes (ECHO) program. ECHO research programs (cohorts) were reviewed. Only those who had or were currently recruiting during pregnancy were surveyed in 2018 about research recruitment strategies (participant incentives, study burden, community collaboration, and cultural adaptations). Data are presented with cohort characteristics (location, inclusion and exclusion criteria, sociodemographics, medical information, behavioral factors, and biospecimens). Forty-seven of the 84 ECHO pediatric cohorts recruited during pregnancy. Findings demonstrate various recruitment strategies, domains of data collection, and biospecimen collection are all characteristics of successful cohorts. These data that includes over 50,000 children from families across the country, many in underserved areas, will be used for research with the potential to lead to profound policy changes. Policies on prenatal conditions such as maternal age, obesity, depression and drug use can be examined using study data, including biological markers, from pregnancy through childbirth and into childhood will inform national policies on the role of early life exposures and underlying mechanisms of disease progression.