The role of lymphatic vessels in the heart.
The role of lymphatic vessels in the heart.
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DOI：
10.1016/j.pathophys.2009.07.006
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Cui, Yingjie
中科院分区：
文献类型：
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作者：
Cui, Yingjie
尽管心脏淋巴管已经被描述了三个多世纪，但心脏淋巴管在心脏生理调节中的作用及其在心脏病发病机制中的紊乱的研究进展非常缓慢，这主要是由于在发展动物模型和心脏淋巴管成像技术方面的技术挑战。本文综述了在动物和人类心脏研究中发现，阻断心脏淋巴流动可导致多种形式的心脏损伤，包括心脏淋巴水肿、心脏瓣膜变形、冠状动脉损伤、传导障碍、心肌损伤和心功能不佳。相反，改善心脏淋巴流量可能会对心脏病发作(心肌梗死)后的心功能产生有益影响。此外，本文综述了最近关于产生心脏淋巴流的力量的假说，其中讨论了心外膜下和心肌中部的心肌细胞同步收缩引起淋巴流的作用。最后，对血管周围淋巴管重塑失败导致血管损伤的可能机制进行了讨论。
Although cardiac lymphatic vessels have been described for over three centuries, research progress on the role of cardiac lymphatic vessels in regulating cardiac physiology and their disturbances in the pathogenesis of cardiac disease has progressed very slowly, largely due to technical challenges in developing both animal models and cardiac lymphatic vascular imaging technologies. This review summarizes evidence showing that blocking cardiac lymph flow may contribute to several forms of cardiac injury including cardiac lymphedema, cardiac valvular deformation, coronary arterial injury, conduction disturbances, myocardial injury, and poor heart performance in animal and human heart studies. Conversely, improving cardiac lymph flow may have beneficial effects on heart function after heart attack (myocardial infarction). In addition, this review summarizes recent hypotheses about the forces generating cardiac lymph flow, in which the role of both the subepicardial and mid-myocardial myocytes synchronized contractions causing lymph flow is discussed. Lastly, possible mechanisms of blood vessel injury caused by the failure of perivascular lymphatic remodeling are discussed.