Calixplatin: novel potential anticancer agent based on the platinum complex with functionalized calixarene
Calixplatin: novel potential anticancer agent based on the platinum complex with functionalized calixarene
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DOI：
10.1080/00958972.2014.890718
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发表时间：
2014-02-01
影响因子：
1.9
通讯作者：
Dilmaghani, Karim Akbari
中科院分区：
文献类型：
--
作者：
Pur, Fazel Nasuhi;Dilmaghani, Karim Akbari
合成了具有四个铂(II)中心的功能化杯芳烃作为潜在的抗癌剂。比色细胞毒性测试表明，相对于卡铂，它对三种不同的人类癌症（非小细胞肺癌、肝细胞癌和乳腺癌）细胞系具有增强的活性。它对肺癌细胞系具有最强的细胞毒性（IC50=2.6M）。
A functionalized calixarene with four platinum(II) centers was synthesized as a potential anticancer agent. The colorimetric cytotoxicity tests showed that it has amplified activity with respect to carboplatin against three different human carcinoma (non-small-cell lung, hepatocellular, and breast cancer) cell lines. It was most cytotoxic against the lung cancer cell line (IC50=2.6M).