Cytokinetic abscission is an acute G1 event
Cytokinetic abscission is an acute G1 event
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DOI：
10.4161/15384101.2014.956486
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发表时间：
2014-11-01
期刊：
影响因子：
4.3
通讯作者：
Tzur, Amit
中科院分区：
文献类型：
--
作者：
Gershony, Ofir;Pe'er, Tal;Tzur, Amit
动物细胞分裂以连接两个子细胞的微管和膜细胞间桥的切断而结束。该过程被称为细胞动力学分裂（cytokinetic discrimination，简称crimination），被广泛认为是胞质分裂的最后一步，细胞周期的最后一步。最近已经取得了重大突破，阐明了细胞周期的机制方面，然而，哺乳动物细胞周期的时间仍然不清楚。在这项研究中，我们仔细测量了分裂细胞中表达G1报告基因的细胞分裂的发生和进展。我们的结论是，细胞进入G1期后很长时间内开始脱落。将细胞周期的最后一步与G1联系在一起是超越语义学的，因为它基本上假定细胞周期的最后一步是在下一个周期中调节的，并且很可能是由下一个周期调节的。
Animal cell division ends with the cutting of the microtubule and membrane intercellular bridge connecting the 2 daughter cells. This process, known as cytokinetic abscission (abscission), is widely regarded as the last step of cytokinesis, i.e., the last step of the cell cycle. Major breakthroughs have been recently achieved, illuminating mechanistic aspects of abscission; however, the timing of abscission with respect to the mammalian cell cycle remains unclear. In this study, we carefully measured the onset and progression of abscission in dividing cells expressing a G1 reporter. We conclude that abscission commences long after cells enter the G1 phase. Affiliating abscission with G1 is beyond semantics since it essentially postulates that the last step of the cell cycle is regulated in, and probably by, the following cycle.