Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+lymphocytopenia
Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+lymphocytopenia
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DOI：
10.1111/j.1600-0609.2011.01619.x
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发表时间：
2011-07-01
影响因子：
3.1
通讯作者：
Gatell, Jose M.
中科院分区：
文献类型：
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作者：
Cervera, Carlos;Fernandez-Aviles, Francesc;Gatell, Jose M.
一名40岁男性患有严重的慢性特发性CD4+淋巴细胞减少症并发机会性感染，通过非清髓性同种异体造血干细胞移植成功治愈。在用氟达拉滨加低剂量全身照射调理后，将通过白细胞分离术从他的HLA相同妹妹处获得的CD34+外周血干细胞输注。 T细胞和骨髓完全嵌合在第+28天实现，并在随访期间保持稳定。患者在手术过程中没有出现感染性并发症。在 35 个月的随访中，他的 CD4+ T 细胞计数为每微升 1019 个细胞。非清髓性同种异体造血干细胞移植应被视为严重特发性 CD4+ 淋巴细胞减少症患者的治疗选择。
A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.