Incidence of uveal melanoma in Europe
Incidence of uveal melanoma in Europe
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DOI：
10.1016/j.ophtha.2007.01.032
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发表时间：
2007-12-01
期刊：
影响因子：
13.7
通讯作者：
Paci, Eugenio
中科院分区：
文献类型：
--
作者：
Virgili, Gianni;Gatta, Gemma;Paci, Eugenio
目的：估计1983年至1994年欧洲葡萄膜黑色素瘤的发病率。设计：来自癌症登记处的数据的发病率分析，这些数据与基于欧洲癌症登记处的癌症患者生存和护理研究一致（欧洲援外社）（1983年至1994年诊断的病例）。6673例眼部黑色素瘤患者的资料（根据国际肿瘤学疾病分类形态代码8720至8780定义[黑色素瘤]）和国际疾病分类9（ICD 9）编码190.0 [虹膜和睫状体]、190.5 [视网膜]、190.6 [脉络膜]和190.9 [未指明的眼部位置]）。发病率比（IRRs）从一个多层次的泊松回归model.Main结果测量：发病率和与人口和地理variables.Results相关的IRRs：标准化发病率从南到北增加跨注册，从最低的8每百万在挪威和丹麦。在大多数英国登记研究中，纳入眼部位置不明的肿瘤（代码190.9）增加了发病率，但在其他地理区域，该代码很少用于葡萄膜黑色素瘤。发病率在55岁之前显著增加（IRR，1.46/5年; 95%置信区间[CI]，1.36-1.57），但在75岁之后趋于平稳（IRR，0.99/5年; 95% CI，0.93-1.05），中间水平居中（IRR，1.18/5年; 95% CI，1.12-1.23）。男性中也较高（IRR，1.22; 95% CI，1.16-1.28）。在研究期间，发病率保持稳定，但证明了队列效应，这是1910年至1935年期间出生的人发病率较高的原因（P = 0.005）。发病率随纬度的增加（P = 0.008），这解释了率之间的最大差异areas.Conclusions：在这个大系列的葡萄膜黑色素瘤，我们发现稳定的发病率在1983年至1994年。从北到南逐渐降低的梯度支持了眼色素沉着的保护作用。欧洲眼科医生应制定指南，使用ICD分类标准化保守治疗的肿瘤编码，以改善癌症登记处对葡萄膜黑色素瘤的登记和监测。
Purpose: To estimate incidence rates of uveal melanoma in Europe from 1983 to 1994.Design: Incidence analysis of data from cancer registries adhering to the European Cancer Registry-based study on survival and care of cancer patients (EUROCARE) (cases diagnosed from 1983 to 1994).Participants: Data of 6673 patients with ocular melanoma (as defined by International Classification of Diseases for Oncology morphology codes 8720 to 8780 [melanoma] and International Classification of Diseases 9 (ICD9) codes 190.0 [iris and ciliary body], 190.5 [retina], 190.6 [choroid], and 190.9 [unspecified ocular location]) from 33 cancer registries of 16 European countries.Methods: Incidence rate ratios (IRRs) were obtained from a multilevel Poisson regression model.Main Outcome Measures: Incidence rates and IRRs associated with demographic and geographic variables.Results: Standardized incidence rates increased from south to north across registries, from a minimum of 8 per million in Norway and Denmark. The inclusion of tumors with unspecified ocular location (code 190.9) increased incidence rates in most United Kingdom registries, but not in the other geographic areas, where this code was seldom used for uveal melanomas. Incidence increased noticeably up to age 55 (IRR, 1.46 per 5 years; 95% confidence interval [Cl], 1.36-1.57) but leveled off after age 75 (IRR, 0.99 per 5 years; 95% Cl, 0.93-1.05), with intermediate levels midway (IRR, 1.18 per 5 years; 95% Cl, 1.12-1.23). It was also higher in males (IRR, 1.22; 95% Cl, 1.16-1.28). Rates were stable during the study period, but a cohort effect was evidenced, accounting for higher incidence rates in people born during the period 1910 to 1935 (P = 0.005). Incidence increased with latitude (P = 0.008), which explained most differences in rates among areas.Conclusions: In this large series of uveal melanomas, we found stable incidence during the years 1983 to 1994. The north-to-south decreasing gradient supports the protective role of ocular pigmentation. European ophthalmologists should develop guidelines to standardize the coding of tumors treated conservatively using the ICD classification to improve the registration and surveillance of uveal melanoma by cancer registries.