Telomere length is heritable and genetically correlated with lifespan in a wild bird
Telomere length is heritable and genetically correlated with lifespan in a wild bird
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端粒长度是可遗传的，并且与野生鸟类的寿命具有遗传相关性
DOI：
10.1111/mec.15807
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发表时间：
2021
影响因子：
4.9
通讯作者：
S. Bouwhuis
中科院分区：
文献类型：
--
作者：
Oscar Vedder;M. Moiron;Coraline Bichet;C. Bauch;S. Verhulst;P. Becker;S. Bouwhuis
端粒是真核生物染色体末端的保护帽，随着年龄的增长和对压力或资源需求条件的反应而缩短。它们的长度预测了各种动物的个体健康和寿命，但所观察到的端粒长度与寿命之间的正相关性是否是环境诱导的，或者是由于共同的遗传基础而在受孕时设定的，尚未在野生动物中进行测试。我们应用定量遗传“动物模型”纵向端粒测量收集超过10年的时间从个人的野生海鸟（普通燕鸥; Sterna hirundo）与已知的血统。我们发现，在表型和遗传水平上，个体间端粒缩短随年龄的变化没有变化，成年端粒长度只有一个小的永久性环境影响。相反，我们发现端粒长度是高度遗传的，并且与寿命有很强的遗传正相关性。个体之间在受孕时就存在的这种遗传差异可能是迄今为止未被充分认识的躯体状态变异的组成部分。
Telomeres are protective caps at the end of eukaryotic chromosomes that shorten with age and in response to stressful or resource‐demanding conditions. Their length predicts individual health and lifespan across a wide range of animals, but whether the observed positive association between telomere length and lifespan is environmentally induced, or set at conception due to a shared genetic basis, has not been tested in wild animals. We applied quantitative genetic “animal models” to longitudinal telomere measurements collected over a 10‐year period from individuals of a wild seabird (common tern; Sterna hirundo) with known pedigree. We found no variation in telomere shortening with age among individuals at the phenotypic and genetic level, and only a small permanent environmental effect on adult telomere length. Instead, we found telomere length to be highly heritable and strongly positively genetically correlated with lifespan. Such heritable differences between individuals that are set at conception may present a hitherto underappreciated component of variation in somatic state.
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影响因子：
11.1
作者：
V. Zakian
通讯作者：
V. Zakian
影响因子：
3.3
作者：
D. Houle
通讯作者：
D. Houle
对比个体间和个体内特征对长寿海鸟死亡风险的影响
影响因子：
4.8
作者：
Zhang H;Vedder O;Becker PH;Bouwhuis S
通讯作者：
Bouwhuis S
DOI：
10.1073/pnas.1113306109
发表时间：
2012-01-31
影响因子：
11.1
作者：
Heidinger, Britt J.;Blount, Jonathan D.;Monaghan, Pat
通讯作者：
Monaghan, Pat