Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community
Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community
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DOI：
10.1080/1059924x.2019.1619644
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发表时间：
2019-05-26
影响因子：
2.4
通讯作者：
Magzamen, Sheryl
中科院分区：
文献类型：
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作者：
Benka-Coker, Wande;Loftus, Christine;Magzamen, Sheryl
目的：探讨农药暴露对农业社区哮喘儿童哮喘加重的短期影响。方法：作为农村环境中哮喘加重因素（AFARE）研究队列的一部分，我们从16名学龄哮喘儿童（n = 139个样本）中获得重复尿液样本。在尿液样本中评估有机磷（OP）农药暴露（二烷基磷酸盐（DAPs））和哮喘加重（白三烯E4 (uLTE4)）的生物标志物。我们使用广义估计方程来检验肌酸酐调整的DAPs（总二甲基烷基磷酸酯（EDM）、总二乙基烷基磷酸酯（EDE）和总二烷基磷酸酯农药（EDAP））的总测量值与uLTE4浓度的关联，并对多个混杂因素进行调整，得到95% ci的β系数。结果：在研究期间，共对16名儿童进行了139次观察，每个受试者的样本总数为1至12个（中位数：10.5）。该人群肌酐调整后的EDE、EDM和EDAP的几何平均值（GM）分别为81.0、71.8和168.0 nmol/g。uLTE4水平的增加与dap暴露的增加一致相关（四分位数范围为μ g/g）： β (EDE): 8.7 (95%CI: 2.8, 14.6)；β (EDM): 1.1 (0.5, 1.7)；beta(EDAP): 4.1（0.7, 7.5）。结论：该研究表明，短期OP暴露与哮喘发病风险增加有关，这一研究表明，在该农业社区哮喘儿童队列中，uLTE4水平升高。需要进一步的研究来证实这些不利影响，并探索这种关系的潜在机制。
Objectives: We explored the short-term impact of pesticide exposure on asthma exacerbation among children with asthma in an agricultural community. Methods: We obtained repeated urine samples from a subset of 16 school-age children with asthma (n = 139 samples) as part of the Aggravating Factors of Asthma in a Rural Environment (AFARE) study cohort. Biomarkers of organophosphate (OP) pesticide exposure (dialkylphosphates (DAPs)), and asthma exacerbation (leukotriene E4 (uLTE4)) were assessed in urine samples. We used generalized estimating equations to examine the association of summed measures of creatinine-adjusted DAPs (total dimethyl alkylphosphate (EDM), total diethyl alkylphosphate (EDE), and total dialkylphosphate pesticides (EDAP)) and uLTE4 concentration, adjusting for multiple confounders, yielding beta-coefficients with 95% CIs. Results: A total of 139 observations were obtained from the 16 children over the study period, the total number of samples per subject ranged from 1 to 12 (median: 10.5). The geometric mean (GM) of creatinine-adjusted EDE, EDM, and EDAP in this population were 81.0, 71.8 and 168.0 nmol/g, respectively. Increase in uLTE4 levels was consistently associated with increased exposures to DAPs (interquartile range in mu g/g): beta(EDE): 8.7 (95%CI: 2.8, 14.6); beta(EDM): 1.1 (0.5, 1.7); beta(EDAP): 4.1 (0.7, 7.5). Conclusion: This study suggests that short-term OP exposure is associated with a higher risk of asthma morbidity, as indicated by increased uLTE4 levels in this cohort of children with asthma in an agricultural community. Additional studies are required to confirm these adverse effects, and explore the mechanisms underlying this relationship.