CHOLECYSTOKININ, VASOACTIVE-INTESTINAL-PEPTIDE AND PEPTIDE HISTIDINE METHIONINE RESPONSES TO FEEDING IN ANOREXIA-NERVOSA
CHOLECYSTOKININ, VASOACTIVE-INTESTINAL-PEPTIDE AND PEPTIDE HISTIDINE METHIONINE RESPONSES TO FEEDING IN ANOREXIA-NERVOSA
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DOI：
10.1016/0167-0115(91)90202-r
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发表时间：
1991-10-01
影响因子：
--
通讯作者：
MCGUIGAN, JE
中科院分区：
文献类型：
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作者：
HARTY, RF;PEARSON, PH;MCGUIGAN, JE
神经性厌食症（Anorexia nervosa，AN）是一种不明原因的以自愿饥饿为特征的综合征。胆囊收缩素被认为是控制饱腹感的神经内分泌调节因子。关于神经性厌食症受试者进食时胃肠道激素反应的信息相对较少。在目前的研究中，我们检查空腹和餐后胆囊收缩素（CCK），血管活性肠肽（VIP）和肽组氨酸蛋氨酸（PHM）在神经性厌食症的主题和对照组的水平。这些研究的结果表明，血浆CCK的液体餐（确保加）在未经治疗的AN受试者的反应是明显不同的观察到的健康对照，无论是在时间模式的肽释放和CCK分泌到循环中的量。在AN患者和对照组中，CCK释放峰值分别出现在进食后30 min和60 min。在未经治疗的AN患者中，CCK的综合释放量约为对照组的两倍。肾功能恢复治疗与对照组CCK释放模式的逆转有关。血浆VIP水平在对照组和实验组受试者进餐后均无变化。与此相反，PHM水平在AN受试者显着大于对照组中观察到的。PHM的释放模式与血浆CCK相似，在30 min时达到峰值，显著高于对照组（P < 0.05）。总之，这些结果表明，血浆CCK和PHM水平的显着差异，在AN受试者喂养时，与对照组相比。这些结果表明，早期和更大的上升，血浆CCK水平在AN受试者进食后，可能有助于在这种情况下的异常饱腹感。
Anorexia nervosa (AN) is a syndrome of unknown cause characterized by voluntary starvation. Cholecystokinin has been implicated as a neuroendocrine regulatory factor in control of satiety. Relatively little information is known about gastrointestinal hormone responses to feeding in subjects with anorexia nervosa. In the present studies, we examine fasting and postprandial levels of cholecystokinin (CCK), vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) in anorexia nervosa subjects and in control individuals. Results of these studies indicate that plasma CCK response to a liquid meal (Ensure Plus) in untreated AN subjects was distinctly different from that observed in healthy controls, both in terms of temporal pattern of peptide released and the amount of CCK secreted into the circulation. Peak levels of CCK release occurred at 30 min following meal ingestion in AN patients and at 60 min in control subjects. Integrated CCK release in untreated AN patients was approximately twice that measured in control individuals. Renutrition therapy was associated with reversion of the pattern of CCK release to that observed in control subjects. Plasma VIP levels were unchanged following meal ingestion in both control and anorexic subjects. In contrast, PHM levels in AN subjects were significantly greater than that observed in control individuals. The pattern of PHM release following liquid meal ingestion was similar to that observed with plasma CCK; namely, peak release of peptide was observed at 30 min which was significantly greater than corresponding control values (P < 0.05). In conclusion, these results demonstrate distinctive differences in plasma CCK and PHM levels in response to feeding in AN subjects when compared to control individuals. These findings suggest that the earlier and greater rise in plasma CCK levels in AN subjects following meal ingestion may contribute to the abnormal sensation of satiety in this condition.