Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture
Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture
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DOI：
10.1161/01.hyp.37.5.1336
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发表时间：
2001-05-01
期刊：
影响因子：
8.3
通讯作者：
Hauner, H
中科院分区：
文献类型：
--
作者：
Skurk, T;Lee, YM;Hauner, H
Plasminogen activator inhibitor (PAI)-1 is the main inhibitor of the fibrinolytic system and was recently shown to be produced by adipose cells. Obesity is associated with an increased production and release of PAI-1 protein. The aim of this study was to investigate the role of angiotensin (Ang) II and its degradation products for PAI-1 release from human adipose cells. For this purpose, we used the model of in vitro differentiated human adipocytes in primary culture. Exposure of human adipocytes to Ang II resulted in a dose- and time-dependent stimulation of PAI-I release into the culture medium. The maximum effect of Ang II was found at a concentration of 10(-5) mol/L for 48 hours, increasing PAI-1 release by 276 +/- 53% compared with control cultures (P
