Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population.
Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population.
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DOI：
10.1097/ypg.0b013e3283539528
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发表时间：
2012-06
影响因子：
0.9
通讯作者：
Berrettini WH
中科院分区：
文献类型：
--
作者：
Ambrose-Lanci LM;Vaswani M;Clarke TK;Zeng A;Lohoff FW;Ferraro TN;Berrettini WH
滥用药物的有益特性是由 Mu-阿片受体 (MOR) 介导的。 MOR 和参与 MOR 信号转导的 MOR 相互作用蛋白 (MORIP) 的遗传变异可能会增加药物依赖的风险。 MORIP（B-arrestin）在 MOR 运输的调节中发挥着重要作用，因此突出它作为成瘾表型的候选基因。在这项病例对照关联研究中，对可卡因 (n=336) 和阿片类药物依赖 (n=335) 患者和对照 (n=656) 的 DNA 样本进行了 7 个单核苷酸多态性 (SNP) 的基因分型（rs11868227、rs3786047、rs4522461、rs1045280、rs2271167、 rs2036657 和 rs4790694）跨 ARRB2（编码 B-arrestin 2 蛋白的基因）。对于所分析的任何 SNP，药物依赖性个体和对照个体之间的基因型或等位基因频率没有观察到显着差异。单倍型分析同样呈阴性。需要进一步的研究来确定 ARRB2（或其他 MORIP）的变异是否与不同种族人群的可卡因或阿片类药物依赖有关，或者它们是否会带来对其他滥用药物的依赖所特有的风险。
The rewarding properties of drugs of abuse are mediated by the Mu-Opioid Receptor (MOR). Genetic variation in MOR and MOR interacting proteins (MORIPs) involved in MOR signaling may increase risk for drug dependence. The MORIP, B-arrestin, plays an important role in the regulation of MOR trafficking thereby highlighting it as a candidate gene for addiction phenotypes. In this case-control association study, DNA samples from cocaine (n=336) and opioid-dependent (n=335) patients and controls (n=656) were genotyped for 7 single nucleotide polymorphisms (SNPs) (rs11868227, rs3786047, rs4522461, rs1045280, rs2271167, rs2036657, and rs4790694) across ARRB2, the gene encoding the B-arrestin 2 protein. No significant differences were observed in genotype or allele frequency between drug dependent and control individuals for any of the SNPs analyzed. Haplotype analysis was similarly negative. Further studies are needed to determine whether variation in ARRB2 (or other MORIPs) are relevant to cocaine or opioid dependence in different ethnic populations or if they confer risk that is specific to dependence on other drugs of abuse.