Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India.
Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India.
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DOI：
10.3390/ijerph18010183
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发表时间：
2020-12-29
影响因子：
--
通讯作者：
Hibberd PL
中科院分区：
文献类型：
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作者：
Parikh R;Rao SR;Kukde R;O'Connor GT;Patel A;Hibberd PL
背景资料：在印度，许多家庭在低效率的条件下燃烧生物质燃料，导致颗粒物和环境毒素的复杂环境，称为家庭空气污染（HAP）。孕妇特别容易受到伤害，因为她们及其胎儿可能遭受HAP的不良后果。呼出气一氧化氮分数（FeNO）是一种非侵入性的，未充分利用的工具，可以作为气道炎症的替代品。我们评估了呼吸道疾病的患病率，使用肺部问卷调查和FeNO测量，在印度农村的孕妇谁利用生物质燃料作为能源在他们的家。方法：我们前瞻性研究了60名孕妇在其第一和第二个三个月居住在附近的村庄纳格布尔，印度中部。我们测量了FeNO水平（ppb）、圣乔治呼吸问卷（SGRQ-C）评分和改良医学研究理事会（mMRC）呼吸困难量表。我们使用双尾t检验评估了使用生物质燃料和使用液化石油气（LPG）的妇女之间结果分布的差异。结果：65例受试者（32例生物质家庭; 28例液化石油气家庭; 5例无法完成）入组研究。年龄、教育水平和二手烟暴露在两组之间具有可比性。生物质组的FeNO水平高于LPG组（25.4 ppb vs. 8.6 ppb; p值= 0.001）。平均复合SGRQ-C评分存在差异（27.1生物量vs. 10.8 LPG; p值< 0.001），包括症状的3个小计评分（47.0生物量vs. 20.2 LPG; p值< 0.001），活性（36.4生物量对比16.5 LPG; p值< 0.001）和影响（15.9生物量对比5.2 LPG; p值< 0.001）。生物质组的mMRC呼吸困难评分也高于LPG组（2.9 vs. 0.5; p < 0.001）。结论：生物质燃料暴露受试者的FeNO水平升高和呼吸困难评分升高证实了妊娠期间这种暴露对呼吸系统的不良影响。更重要的是，FeNO可能是一种有用的，非侵入性的炎症生物标志物，可以帮助更好地了解生物质烟雾对孕妇的生理影响。在未来，需要更大规模的研究来表征FeNO在暴露于HAP的人群中的效用。
Background: In India, biomass fuel is burned in many homes under inefficient conditions, leading to a complex milieu of particulate matter and environmental toxins known as household air pollution (HAP). Pregnant women are particularly vulnerable as they and their fetus may suffer from adverse consequences of HAP. Fractional exhaled nitric oxide (FeNO) is a noninvasive, underutilized tool that can serve as a surrogate for airway inflammation. We evaluated the prevalence of respiratory illness, using pulmonary questionnaires and FeNO measurements, among pregnant women in rural India who utilize biomass fuel as a source of energy within their home. Methods: We prospectively studied 60 pregnant women in their 1st and 2nd trimester residing in villages near Nagpur, Central India. We measured FeNO levels in parts per billion (ppb), St. George’s Respiratory Questionnaire (SGRQ-C) scores, and the Modified Medical Research Council (mMRC) Dyspnea Scale. We evaluated the difference in the outcome distributions between women using biomass fuels and those using liquefied petroleum gas (LPG) using two-tailed t-tests. Results: Sixty-five subjects (32 in Biomass households; 28 in LPG households; 5 unable to complete) were enrolled in the study. Age, education level, and second-hand smoke exposure were comparable between both groups. FeNO levels were higher in the Biomass vs. LPG group (25.4 ppb vs. 8.6 ppb; p-value = 0.001). There was a difference in mean composite SGRQ-C score (27.1 Biomass vs. 10.8 LPG; p-value < 0.001) including three subtotal scores for Symptoms (47.0 Biomass vs. 20.2 LPG; p-value< 0.001), Activity (36.4 Biomass vs. 16.5 LPG; p-value < 0.001) and Impact (15.9 Biomass vs. 5.2 LPG; p-value < 0.001). The mMRC Dyspnea Scale was higher in the Biomass vs. LPG group as well (2.9 vs. 0.5; p < 0.001). Conclusion: Increased FeNO levels and higher dyspnea scores in biomass-fuel-exposed subjects confirm the adverse respiratory effects of this exposure during pregnancy. More so, FeNO may be a useful, noninvasive biomarker of inflammation that can help better understand the physiologic effects of biomass smoke on pregnant women. In the future, larger studies are needed to characterize the utility of FeNO in a population exposed to HAP.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
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作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
10.4
作者：
Bonjour S;Adair-Rohani H;Wolf J;Bruce NG;Mehta S;Prüss-Ustün A;Lahiff M;Rehfuess EA;Mishra V;Smith KR
通讯作者：
Smith KR
在洪都拉斯妇女中，生物质烹饪炉和分数呼出的一氧化氮（Feno）水平暴露于家庭空气污染。
DOI：
10.3390/ijerph15112544
发表时间：
2018-11-13
影响因子：
--
作者：
Benka-Coker ML;Clark ML;Rajkumar S;Young BN;Bachand AM;Balmes JR;Brook R;Nelson TL;Volckens J;Reynolds SJ;Wilson A;L'Orange C;Good N;Quinn C;Koehler K;Africano S;Osorto Pinel A;Peel JL
通讯作者：
Peel JL
影响因子：
3.7
作者：
Amegah AK;Quansah R;Jaakkola JJ
通讯作者：
Jaakkola JJ
影响因子：
4.4
作者：
Alexander, Donee;Linnes, Jacqueline Callihan;Larson, Timothy
通讯作者：
Larson, Timothy