TOMOGRAPHIC IMAGING OF THE HUMAN THYROID USING I-124
TOMOGRAPHIC IMAGING OF THE HUMAN THYROID USING I-124
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DOI：
10.1210/jcem-63-4-918
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发表时间：
1986-10-01
影响因子：
5.8
通讯作者：
DONATH, A
中科院分区：
文献类型：
--
作者：
FREY, P;TOWNSEND, D;DONATH, A
在接收了100到300亩之后。采用高分辨率正电子相机对64例不同类型甲状腺疾病患者的正电子放射同位素124I（半衰期4.2天）进行成像。通过一次10- 15分钟的扫描，获得了甲状腺内放射性碘摄取分布的三维图像。该图像可以看作是一系列2mm厚的横切面、矢状面或正切面，也可以看作是一个三维阴影面。甲状腺的功能体积可以通过计算甲状腺表面内的体积元素（体素）来估计。估计的精确度在6-15%之间变化，取决于甲状腺的临床状态大小。体积估计程序通过幻影和随后接受部分甲状腺切除术的患者的甲状腺得到验证。这种三维成像技术可能对甲状腺疾病的诊断和治疗有用。
After receiving between 100 and 300 .mu.Ci of the positron-emitting radioisotope 124I (half-life, 4.2 days), 64 patients with a variety of thyroid disorders were imaged with a high resolution positron camera. A 3-dimensional image of the distribution of radioiodine uptake within the thyroid was obtained from a single 10- to 15-min scan. This image may be viewed as a sequence of 2-mm thick transverse, sagittal, or frontal sections or as a 3-dimensional shaded surface. The functional volume of the thyroid may be estimated by counting the volume elements (voxels) inside the thyroid surface. The precision of the estimate varied from 6-15%, depending on the size of clinical status of the thyroid. The volume estimation procedure was validated with phantoms and with the thyroids of patients who subsequently underwent partial thyroidectomy. This 3-dimensional imaging technique may be useful for diagnosis and management of thyroid diseases.