Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway.
Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway.
复制标题
袖状胃切除术可改善糖尿病引起的心脏肥大，且与 MAPK 信号通路相关
DOI：
10.3389/fphys.2021.785799
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发表时间：
2021
影响因子：
4
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Xu Q;Ding H;Li S;Dong S;Li L;Shi B;Zhong M;Zhang G
背景：心脏肥厚是糖尿病性心肌病（DCM）的主要病理表现，是糖尿病的重要并发症。减肥手术已被证明可以缓解DCM；然而，它是否能减轻糖尿病引起的心脏肥厚尚不清楚。方法：糖尿病大鼠和肥胖大鼠在糖尿病16周后行袖式胃切除术（SG）。SG后8周处死大鼠。比较对照组（CON组）、糖尿病组（DM组）、假手术组（sham组）和SG组大鼠的代谢参数、心功能参数、心肌糖摄取、形态学和组织学变化以及丝裂原活化蛋白激酶（MAPKs）的表达水平。结果：与SHAM组比较，SG组血糖、体重、胰岛素抵抗等代谢指标均有明显改善。SG治疗后心肌形态学和组织学指标均有明显改善。此外，SG后心肌糖摄取和心功能逆转。此外，SG后mapk的磷酸化被抑制，包括p38 mapk、c-Jun n末端激酶（JNKs）和细胞外信号调节激酶1/2 （ERK1/2）。使ERK1/2去磷酸化的DUSP6在SG后表达上调。这些发现表明，SG改善糖尿病诱导的心肌肥厚与MAPK信号通路有关。结论：上述结果表明，SG对糖尿病诱导的心肌肥厚的改善与抑制MAPK信号通路和上调DUSP6密切相关。因此，本研究为治疗糖尿病性心肌肥厚提供了一种新的策略。
Background: Cardiac hypertrophy as a main pathological manifestation of diabetic cardiomyopathy (DCM), is a significant complication of diabetes. Bariatric surgery has been proven to relieve DCM; however, whether it can alleviate diabetes-induced cardiac hypertrophy is undefined. Methods: Diabetic and obese rats were performed sleeve gastrectomy (SG) after having diabetes for 16weeks. The rats were euthanized 8weeks after SG. Metabolic parameters, heart function parameters, myocardial glucose uptake, morphometric and histological changes, and the expression level of mitogen-activated protein kinases (MAPKs) were determined and compared among the control group (CON group), diabetes mellitus group (DM group), sham operation group (SHAM group), and SG group. Results: Compared with the SHAM group, the blood glucose, body weight, insulin resistance, and other metabolic parameters were significantly improved in the SG group. There was also a marked improvement in myocardial morphometric and histological parameters after SG. Furthermore, the myocardial glucose uptake and heart function were reversed after SG. Additionally, the phosphorylation of MAPKs was inhibited after SG, including p38 MAPKs, c-Jun N-terminal kinases (JNKs), and extracellular signal-regulated kinases 1/2 (ERK1/2). The expression of DUSP6, which dephosphorylates ERK1/2, was upregulated after SG. These findings suggest that SG ameliorated diabetes-induced cardiac hypertrophy correlates with the MAPK signaling pathway. Conclusion: These results showed that diabetes-induced cardiac hypertrophy was ameliorated after SG was closely related to the inhibition of the MAPK signaling pathway and upregulation of DUSP6. Therefore, this study provides a novel strategy for treating diabetes-induced cardiac hypertrophy.
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影响因子：
4.9
作者：
de Simone G;Devereux RB;Chinali M;Lee ET;Galloway JM;Barac A;Panza JA;Howard BV
通讯作者：
Howard BV
影响因子：
37.8
作者：
Kehat I;Molkentin JD
通讯作者：
Molkentin JD
影响因子：
20.1
作者：
Auger-Messier M;Accornero F;Goonasekera SA;Bueno OF;Lorenz JN;van Berlo JH;Willette RN;Molkentin JD
通讯作者：
Molkentin JD
影响因子：
4.8
作者：
Echouffo-Tcheugui, Justin B.;Xu, Haolin;Fonarow, Gregg C.
通讯作者：
Fonarow, Gregg C.
影响因子：
7.9
作者：
Ba Lina;Gao Jingquan;Sun Hongli
通讯作者：
Sun Hongli