An update on the rapid advances in malaria parasite cell biology.
An update on the rapid advances in malaria parasite cell biology.
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疟疾寄生虫细胞生物学快速进展的最新进展。
DOI：
10.1016/j.pt.2010.03.007
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发表时间：
2010
影响因子：
9.6
通讯作者：
Prigge,SeanT
中科院分区：
文献类型：
--
作者：
Coppens,Isabelle;Sullivan,DavidJ;Prigge,SeanT
分子鉴定技术和系统发育分析的最新进展揭示了非洲存在以前未识别的采采蝇传播的锥虫。这在包括人类和动物锥虫病的病原体的相对熟知的病原体组中是令人惊讶的。尽管遗传分化程度值得分类学的认可，但这些新锥虫中只有一种被命名为新物种;增加的多样性在很大程度上被忽视或被视为一种不方便的并发症。然而，这些锥虫中的一些已经表现出致病性，而另一些则与已知的病原体密切相关，并且可能具有这种特征。我们应该首先承认这些新型锥虫的存在，然后采取措施研究它们的宿主范围，对牲畜的致病性和对化疗的反应。
Recent advances in molecular identification techniques and phylogenetic analysis have revealed the presence of previously unidentified tsetse-transmitted trypanosomes in Africa. This is surprising in a comparatively well-known group of pathogens that includes the causative agents of human and animal trypanosomiasis. Despite levels of genetic divergence that warrant taxonomic recognition, only one of these new trypanosomes has been named as a new species; the increased diversity is largely ignored or regarded as an inconvenient complication. Yet, some of these trypanosomes have demonstrated pathogenicity, whereas others are closely related to known pathogens, and might share this trait. We should first acknowledge that these novel trypanosomes exist and then take steps to investigate their host range, pathogenicity to livestock and response to chemotherapy.