Pain in the trigeminal system:: irritation of the nasal mucosa using short- and long-lasting stimuli
Pain in the trigeminal system:: irritation of the nasal mucosa using short- and long-lasting stimuli
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DOI：
10.1016/s0167-8760(02)00150-2
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发表时间：
2003-02-01
影响因子：
3
通讯作者：
Lötsch, J
中科院分区：
文献类型：
--
作者：
Hummel, T;Mohammadian, P;Lötsch, J
该论文描述了使用短期和长期疼痛刺激对人类进行鼻内刺激的方法。短期疼痛是由气态二氧化碳引起的，而持久疼痛是由干燥空气流引起的。这两种模型都对其主要决定因素进行了探索，例如刺激持续时间、刺激强度或重复刺激。短期、非炎症性疼痛刺激似乎提供了 A(δ) 纤维功能的具体指标，而对持久、炎症性疼痛的反应似乎表明了 C 纤维功能。对两种类型的疼痛刺激的反应均由镇痛药物调节。由于这些经过充分研究的模型可以详细而精确地分析对鼻内伤害感受的调节作用，因此它们似乎适合研究鼻内刺激的细微变化，例如鼻内刺激的细微变化。由环境因素诱发。 (C) 2002 Elsevier Science B.V. 保留所有权利。
The paper describes methods which allow intranasal irritation using short- and long-lasting painful stimuli in humans. Short-lasting pain is induced by gaseous CO2, while long-lasting pain is induced by a stream of dry air. Both models have been explored regarding their major determinants, e.g. stimulus duration, stimulus intensity, or repeated stimulation. Short-lasting, non-inflammatory pain stimuli seem to provide specific indicators of A(delta)-fiber function, while responses to long-lasting, inflammatory pain appear to be indicative of C-fiber function. Responses to both types of painful stimuli are modulated by analgesic drugs. As these well-investigated models allow the detailed and precise analysis of modulatory effects on intranasal nociception, they appear to be suited for the investigation of subtle changes of intranasal irritation, e.g. induced by environmental agents. (C) 2002 Elsevier Science B.V. All rights reserved.