[18F]fluorodeoxyglucose as a memory marker of transient myocardial ischaemia
[18F]fluorodeoxyglucose as a memory marker of transient myocardial ischaemia
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DOI：
10.1097/mnm.0b013e328013eaa5
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发表时间：
2007-02-01
影响因子：
1.5
通讯作者：
Arrighi, James A.
中科院分区：
文献类型：
--
作者：
Abbott, Brian G.;Liu, Yi-Hwa;Arrighi, James A.
背景实验数据表明，急性心肌缺血时葡萄糖利用增加，并可持续24小时。是否氟代脱氧葡萄糖（FDG）的摄取可以成像为一个记忆标记的缺血在humans is unknown.Methods患者轻度至中度缺血运动单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）进行重复运动试验1-2周内。运动后60 min注射FDG后进行正电子发射断层扫描（PET）。SPECT和PET图像进行了视觉评估，辅助圆周轮廓为基础的分析修改为“热点”imaging.Results 12名男子与应力SPECT缺血（平均年龄，69岁，9与已知的冠状动脉疾病）进行了研究。第一次（SPECT）和第二次（FDG PET）运动试验的平均心率-血压乘积相似（22 841 7321 vs. 22 680 7393 mmHg x bpm，P = NS）。总体而言，12例患者中有6例有FDG摄取的证据。FDG阳性和FDG阴性患者的SPECT缺血程度相似（总差异评分10.6 +/- 6.9 vs. 8.0 +/- 1.6，P = NS）。一个积极的FDG扫描的所有患者都摄取在缺血SPECT区域或在已知的CAD通过angiography.Conclusion区域心肌摄取FDG增强，即使在运动后1小时注射压力在一个子集的患者缺血运动SPECT MPI。在缺血发作后1小时注射FDG摄取成像的能力表明FDG作为短暂性缺血的记忆标记物的潜在效用。
Background Experimental data have shown that glucose utilization increases during acute myocardial ischaemia, and may persist for up to 24 h. Whether fluorodeoxyglucose (FDG) uptake can be imaged as a memory marker of ischaemia in humans is unknown.Methods Patients with mild-to-moderate ischaemia on exercise single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) underwent repeat exercise testing within 1-2 weeks. Positron emission tomography (PET) was performed after injection of FDG 60 min post-exercise. SPECT and PET images were assessed visually, aided by circumferential profile-based analysis modified for 'hot-spot' imaging.Results Twelve men with stress SPECT ischaemia (mean age, 69 years; nine with known coronary artery disease) were studied. The mean rate-pressure products for the first (SPECT) and second (FDG PET) exercise tests were similar (22 841 7321 vs. 22 680 7393 mmHg x bpm, P = NS). Overall, six of 12 patients studied had evidence of FDG uptake. The extent of ischaemia on SPECT was similar in FDG positive and FDG negative patients (summed difference score 10.6 +/- 6.9 vs. 8.0 +/- 1.6, P = NS). All patients with a positive FDG scan had uptake in either an ischaemic SPECT region or in a territory with known CAD by angiography.Conclusion Regional myocardial uptake of FDG is enhanced even when injected 1 h post-exercise stress in a subset of patients with ischaemia on exercise SPECT MPI. The ability to image FDG uptake injected 1 h after an ischaemic episode suggests the potential utility of FDG as a memory marker of transient ischaemia.