Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.
Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.
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DOI：
10.12688/f1000research.17717.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Pavlinkova, Gabriela
中科院分区：
文献类型：
--
作者：
Fritzsch, Bernd;Elliott, Karen L;Pavlinkova, Gabriela
与我们周围的世界互动需要提取有意义的信号来指导行为。哺乳动物的六种感官（嗅觉、视觉、躯体感觉、听觉、平衡和味觉）中的每一种都有一个独特的主要地图，可以提取感官特定的信息。周围的感觉系统和中枢神经系统中的靶神经元独立发展，必须发展特定的连接以进行适当的感觉处理。此外，在几个地图中，感觉地图形成的调节是独立的，并在中枢靶神经元发育之前。本文综述了目前对哺乳动物六种感官的初级地图形成的理解水平。细胞周期退出，结合不完全理解的分子及其调节，提供了进一步细化的活性的化学亲和力介导的主要地图。细胞周期退出、分子导向和活性介导的细化之间的相互作用是视觉和平衡系统中多余器官移植后优势条纹的基础。对初级地图形成的更高级的理解可以通过引导恢复的感觉器官与其中枢神经系统目标的正确功能连接形成来有益于受损感觉的持续恢复尝试。
Interaction with the world around us requires extracting meaningful signals to guide behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing, balance, and taste) has a unique primary map that extracts sense-specific information. Sensory systems in the periphery and their target neurons in the central nervous system develop independently and must develop specific connections for proper sensory processing. In addition, the regulation of sensory map formation is independent of and prior to central target neuronal development in several maps. This review provides an overview of the current level of understanding of primary map formation of the six mammalian senses. Cell cycle exit, combined with incompletely understood molecules and their regulation, provides chemoaffinity-mediated primary maps that are further refined by activity. The interplay between cell cycle exit, molecular guidance, and activity-mediated refinement is the basis of dominance stripes after redundant organ transplantations in the visual and balance system. A more advanced level of understanding of primary map formation could benefit ongoing restoration attempts of impaired senses by guiding proper functional connection formations of restored sensory organs with their central nervous system targets.